| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50162097 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306530 (CHEMBL829597) |
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| IC50 | 18±n/a nM |
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| Citation |  Harper, S; Pacini, B; Avolio, S; Di Filippo, M; Migliaccio, G; Laufer, R; De Francesco, R; Rowley, M; Narjes, F Development and preliminary optimization of indole-N-acetamide inhibitors of hepatitis C virus NS5B polymerase. J Med Chem48:1314-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50162097 |
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| n/a |
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| Name | BDBM50162097 |
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| Synonyms: | 3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-(4-methoxy-phenyl)-1H-indole-6-carboxylic acid | CHEMBL179970 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N2O4 |
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| Mol. Mass. | 434.5274 |
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| SMILES | COc1ccc(cc1)-c1c(C2CCCCC2)c2ccc(cc2n1CC(=O)N(C)C)C(O)=O |
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| Structure | 
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