Ki Summary

Reaction Details

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Target

Liver carboxylesterase 1

Ligand

BDBM50100865

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_305509 (CHEMBL831110)

IC50

1000±n/a nM

Citation

Boger, DL; Miyauchi, H; Du, W; Hardouin, C; Fecik, RA; Cheng, H; Hwang, I; Hedrick, MP; Leung, D; Acevedo, O; Guimarães, CR; Jorgensen, WL; Cravatt, BF Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics. J Med Chem48:1849-56 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Liver carboxylesterase 1

Name:

Liver carboxylesterase 1

Synonyms:

Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1)

Type:

Protein

Mol. Mass.:

62520.83

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

567

Sequence:

MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL

BDBM50100865

n/a

Name

BDBM50100865

Synonyms:

(Z)-1-(oxazolo[4,5-b]pyridin-2-yl)octadec-9-en-1-one | (Z)-1-Oxazolo[4,5-b]pyridin-2-yl-octadec-9-en-1-one | 1-Oxazolo[4,5-b]pyridin-2-yl-nonadec-10-en-2-one | CHEMBL35925

Type

Small organic molecule

Emp. Form.

C24H36N2O2

Mol. Mass.

384.5548

SMILES

CCCCCCCC\C=C/CCCCCCCC(=O)c1nc2ncccc2o1

Structure