| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 3 |
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| Ligand | BDBM50117461 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306872 (CHEMBL828678) |
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| IC50 | 30±n/a nM |
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| Citation |  De Lucca, GV; Kim, UT; Vargo, BJ; Duncia, JV; Santella, JB; Gardner, DS; Zheng, C; Liauw, A; Wang, Z; Emmett, G; Wacker, DA; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Das, AM; Davies, P; Yeleswaram, S; Graden, DM; Solomon, KA; Newton, RC; Trainor, GL; Decicco, CP; Ko, SS Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem48:2194-211 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 3 |
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| Name: | C-C chemokine receptor type 3 |
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| Synonyms: | C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 41053.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51677 |
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| Residue: | 355 |
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| Sequence: | MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
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| BDBM50117461 |
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| n/a |
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| Name | BDBM50117461 |
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| Synonyms: | 3-[3-(3-Acetyl-phenyl)-ureido]-2-[4-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-N-methyl-benzamide | CHEMBL123611 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H33FN4O3 |
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| Mol. Mass. | 516.6064 |
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| SMILES | CNC(=O)c1cccc(NC(=O)Nc2cccc(c2)C(C)=O)c1CN1CCC(Cc2ccc(F)cc2)CC1 |
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| Structure | 
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