| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 2 |
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| Ligand | BDBM50163636 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306389 (CHEMBL828730) |
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| IC50 | 10000±n/a nM |
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| Citation |  De Lucca, GV; Kim, UT; Vargo, BJ; Duncia, JV; Santella, JB; Gardner, DS; Zheng, C; Liauw, A; Wang, Z; Emmett, G; Wacker, DA; Welch, PK; Covington, M; Stowell, NC; Wadman, EA; Das, AM; Davies, P; Yeleswaram, S; Graden, DM; Solomon, KA; Newton, RC; Trainor, GL; Decicco, CP; Ko, SS Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency. J Med Chem48:2194-211 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 2 |
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| Name: | C-C chemokine receptor type 2 |
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| Synonyms: | C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 41932.32 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P41597 |
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| Residue: | 374 |
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| Sequence: | MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN
MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY
HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK
CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR
AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI
NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI
GRAPEASLQDKEGA
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| BDBM50163636 |
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| n/a |
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| Name | BDBM50163636 |
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| Synonyms: | 1-((1R,2S)-2-(((S)-3-(4-fluorobenzyl)piperidin-1-yl)methyl)cyclohexyl)-3-(5-acetyl-4-methylthiazol-2-yl)urea | 1-(5-Acetyl-4-methyl-thiazol-2-yl)-3-{(1R,2S)-2-[(S)-3-(4-fluoro-benzyl)-piperidin-1-ylmethyl]-cyclohexyl}-urea | CHEMBL195433 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H35FN4O2S |
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| Mol. Mass. | 486.645 |
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| SMILES | CC(=O)c1sc(NC(=O)N[C@@H]2CCCC[C@H]2CN2CCC[C@@H](Cc3ccc(F)cc3)C2)nc1C |
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| Structure | 
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