| Reaction Details |
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 | Report a problem with these data |
| Target | Plasmepsin X |
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| Ligand | BDBM50591317 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2199854 (CHEMBL5112370) |
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| IC50 | 7.0±n/a nM |
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| Citation |  Lowe, MA; Cardenas, A; Valentin, JP; Zhu, Z; Abendroth, J; Castro, JL; Class, R; Delaunois, A; Fleurance, R; Gerets, H; Gryshkova, V; King, L; Lorimer, DD; MacCoss, M; Rowley, JH; Rosseels, ML; Royer, L; Taylor, RD; Wong, M; Zaccheo, O; Chavan, VP; Ghule, GA; Tapkir, BK; Burrows, JN; Duffey, M; Rottmann, M; Wittlin, S; Angulo-Barturen, I; Jiménez-Díaz, MB; Striepen, J; Fairhurst, KJ; Yeo, T; Fidock, DA; Cowman, AF; Favuzza, P; Crespo-Fernandez, B; Gamo, FJ; Goldberg, DE; Soldati-Favre, D; Laleu, B; de Haro, T Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of J Med Chem65:14121-14143 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Plasmepsin X |
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| Name: | Plasmepsin X |
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| Synonyms: | 3.4.23.- | PLM10_PLAF7 | PMX | PfPMX | Plasmepsin 10 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65102.67 |
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| Organism: | Plasmodium falciparum (isolate 3D7) |
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| Description: | ChEMBL_119140 |
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| Residue: | 573 |
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| Sequence: | MKRISPLNTLFYLSLFFSYTFKGLKCTRIYKIGTKALPCSECHDVFDCTGCLFEEKESSH
VIPLKLNKKNPNDHKKLQKHHESLKLGDVKYYVNRGEGISGSLGTSSGNTLDDMDLINEE
INKKRTNAQLDEKNFLDFTTYNKNKAQDISDHLSDIQKHVYEQDAQKGNKNFTNNENNSD
NENNSDNENNSDNENNLDNENNLDNENNSDNSSIEKNFIALENKNATVEQTKENIFLVPL
KHLRDSQFVGELLVGTPPQTVYPIFDTGSTNVWVVTTACEEESCKKVRRYDPNKSKTFRR
SFIEKNLHIVFGSGSISGSVGTDTFMLGKHLVRNQTFGLVESESNNNKNGGDNIFDYISF
EGIVGLGFPGMLSAGNIPFFDNLLKQNPNVDPQFSFYISPYDGKSTLIIGGISKSFYEGD
IYMLPVLKESYWEVKLDELYIGKERICCDEESYVIFDTGTSYNTMPSSQMKTFLNLIHST
ACTEQNYKDILKSYPIIKYVFGELIIELHPEEYMILNDDVCMPAYMQIDVPSERNHAYLL
GSLSFMRNFFTVFVRGTESRPSMVGVARAKSKN
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| BDBM50591317 |
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| n/a |
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| Name | BDBM50591317 |
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| Synonyms: | CHEMBL5191783 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30ClN5O2 |
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| Mol. Mass. | 467.991 |
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| SMILES | C[C@H]1C[C@H](CCO1)N1C(=O)C[C@](C)(NC1=N)c1cccc(Nc2ccc(nc2)C2CC2)c1Cl |r| |
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| Structure | 
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