Reaction Details |
| Report a problem with these data |
Target | Cytochrome P450 2D6 |
---|
Ligand | BDBM50591456 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_2200576 (CHEMBL5113092) |
---|
IC50 | >10000±n/a nM |
---|
Citation | Orsi, DL; Pook, E; Bräuer, N; Friberg, A; Lienau, P; Lemke, CT; Stellfeld, T; Brüggemeier, U; Pütter, V; Meyer, H; Baco, M; Tang, S; Cherniack, AD; Westlake, L; Bender, SA; Kocak, M; Strathdee, CA; Meyerson, M; Eis, K; Goldstein, JT Discovery and Structure-Based Design of Potent Covalent PPAR? Inverse-Agonists J Med Chem65:14843-14863 (2022) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Cytochrome P450 2D6 |
---|
Name: | Cytochrome P450 2D6 |
Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
Type: | Protein |
Mol. Mass.: | 55774.82 |
Organism: | Homo sapiens (Human) |
Description: | P10635 |
Residue: | 497 |
Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
|
|
|
BDBM50591456 |
---|
n/a |
---|
Name | BDBM50591456 |
Synonyms: | CHEMBL5207130 |
Type | Small organic molecule |
Emp. Form. | C22H16ClN3O4 |
Mol. Mass. | 421.833 |
SMILES | CCc1ccc(cc1)-c1nc2cc(NC(=O)c3cc(ccc3Cl)[N+]([O-])=O)ccc2o1 |
Structure |
|