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TargetCoagulation factor XIII
LigandBDBM50164216
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304794
IC50 110±n/a nM
Citation Leung-Toung RTam TFWodzinska JMZhao YLowrie JSimpson CDKarimian KSpino M 3-Substituted imidazo[1,2-d][1,2,4]-thiadiazoles: a novel class of factor XIIIa inhibitors. J Med Chem 48:2266-9 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor XIII
Name:Coagulation factor XIII
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:83261.29
Organism:Homo sapiens (Human)
Description:ChEMBL_1475048
Residue:732
Sequence:
MSETSRTAFGGRRAVPPNNSNAAEDDLPTVELQGVVPRGVNLQEFLNVTSVHLFKERWDT
NKVDHHTDKYENNKLIVRRGQSFYVQIDFSRPYDPRRDLFRVEYVIGRYPQENKGTYIPV
PIVSELQSGKWGAKIVMREDRSVRLSIQSSPKCIVGKFRMYVAVWTPYGVLRTSRNPETD
TYILFNPWCEDDAVYLDNEKEREEYVLNDIGVIFYGEVNDIKTRSWSYGQFEDGILDTCL
YVMDRAQMDLSGRGNPIKVSRVGSAMVNAKDDEGVLVGSWDNIYAYGVPPSAWTGSVDIL
LEYRSSENPVRYGQCWVFAGVFNTFLRCLGIPARIVTNYFSAHDNDANLQMDIFLEEDGN
VNSKLTKDSVWNYHCWNEAWMTRPDLPVGFGGWQAVDSTPQENSDGMYRCGPASVQAIKH
GHVCFQFDAPFVFAEVNSDLIYITAKKDGTHVVENVDATHIGKLIVTKQIGGDGMMDITD
TYKFQEGQEEERLALETALMYGAKKPLNTEGVMKSRSNVDMDFEVENAVLGKDFKLSITF
RNNSHNRYTITAYLSANITFYTGVPKAEFKKETFDVTLEPLSFKKEAVLIQAGEYMGQLL
EQASLHFFVTARINETRDVLAKQKSTVLTIPEIIIKVRGTQVVGSDMTVTVQFTNPLKET
LRNVWVHLDGPGVTRPMKKMFREIRPNSTVQWEEVCRPWVSGHRKLIASMSSDSLRHVYG
ELDVQIQRRPSM
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50164216
n/a
NameBDBM50164216
Synonyms:CHEMBL190022 | N-[6-(Imidazo[1,2-d][1,2,4]thiadiazol-3-yl-methyl-amino)-hexyl]-2-nitro-benzenesulfonamide
TypeSmall organic molecule
Emp. Form.C17H22N6O4S2
Mol. Mass.438.524
SMILESCN(CCCCCCNS(=O)(=O)c1ccccc1[N+]([O-])=O)c1n[s+]c2[n-]ccn12
Structure
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