Reaction Details |
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Target | Melanin-concentrating hormone receptor 2 |
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Ligand | BDBM50164255 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302592 (CHEMBL839552) |
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Ki | >3000±n/a nM |
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Citation | McBriar, MD; Guzik, H; Xu, R; Paruchova, J; Li, S; Palani, A; Clader, JW; Greenlee, WJ; Hawes, BE; Kowalski, TJ; O'Neill, K; Spar, B; Weig, B Discovery of bicycloalkyl urea melanin concentrating hormone receptor antagonists: orally efficacious antiobesity therapeutics. J Med Chem48:2274-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Melanin-concentrating hormone receptor 2 |
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Name: | Melanin-concentrating hormone receptor 2 |
Synonyms: | GPR145 | MCHR2 | MCHR2_HUMAN | Melanin Concentrating Hormone 2 | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 2 | SLT |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 38862.16 |
Organism: | Homo sapiens (Human) |
Description: | Melanin Concentrating Hormone 2 GPR145 HUMAN::Q969V1 |
Residue: | 340 |
Sequence: | MNPFHASCWNTSAELLNKSWNKEFAYQTASVVDTVILPSMIGIICSTGLVGNILIVFTII
RSRKKTVPDIYICNLAVADLVHIVGMPFLIHQWARGGEWVFGGPLCTIITSLDTCNQFAC
SAIMTVMSVDRYFALVQPFRLTRWRTRYKTIRINLGLWAASFILALPVWVYSKVIKFKDG
VESCAFDLTSPDDVLWYTLYLTITTFFFPLPLILVCYILILCYTWEMYQQNKDARCCNPS
VPKQRVMKLTKMVLVLVVVFILSAAPYHVIQLVNLQMEQPTLAFYVGYYLSICLSYASSS
INPFLYILLSGNFQKRLPQIQRRATEKEINNMGNTLKSHF
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BDBM50164255 |
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n/a |
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Name | BDBM50164255 |
Synonyms: | 1-[(1S,2R,5S)-5-(2-Cyano-phenyl)-bicyclo[3.1.0]hex-2-yl]-3-(4-fluoro-3-trifluoromethyl-phenyl)-1-[2-((R)-3-hydroxy-pyrrolidin-1-yl)-ethyl]-urea | CHEMBL364500 |
Type | Small organic molecule |
Emp. Form. | C27H28F4N4O2 |
Mol. Mass. | 516.5304 |
SMILES | O[C@@H]1CCN(CCN([C@@H]2CC[C@@]3(C[C@H]23)c2ccccc2C#N)C(=O)Nc2ccc(F)c(c2)C(F)(F)F)C1 |
Structure |
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