Reaction Details |
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Target | RAF proto-oncogene serine/threonine-protein kinase |
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Ligand | BDBM50232424 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2202558 (CHEMBL5115266) |
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IC50 | 370±n/a nM |
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Citation | Zaraei, SO; Al-Ach, NN; Anbar, HS; El-Gamal, R; Tarazi, H; Tokatly, RT; Kalla, RR; Munther, MA; Wahba, MM; Alshihabi, AM; Shehata, MK; Sbenati, RM; Shahin, AI; El-Awady, R; Al-Tel, TH; El-Gamal, MI Design and synthesis of new quinoline derivatives as selective C-RAF kinase inhibitors with potent anticancer activity. Eur J Med Chem238:0 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAF proto-oncogene serine/threonine-protein kinase |
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Name: | RAF proto-oncogene serine/threonine-protein kinase |
Synonyms: | C-Raf Protein Kinase | Proto-oncogene c-RAF (RAF1) | RAF | RAF proto-oncogene
serine/threonine-protein kinase (C-Raf) | RAF1 | RAF1_HUMAN | Raf-1 | Serine/threonine-protein kinase
RAF | Serine/threonine-protein kinase C-Raf | cRaf |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 73082.52 |
Organism: | Homo sapiens (Human) |
Description: | P04049 |
Residue: | 648 |
Sequence: | MEHIQGAWKTISNGFGFKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDPSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTIGDSGVPALPSLTMRRMRESVSRMPVSSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIEDAIRSHSESASPSALSSSPNNL
SPTGWSQPKTPVPAQRERAPVSGTQEKNKIRPRGQRDSSYYWEIEASEVMLSTRIGSGSF
GTVYKGKWHGDVAVKILKVVDPTPEQFQAFRNEVAVLRKTRHVNILLFMGYMTKDNLAIV
TQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL
TVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQDNNPFSFQSDVYSYGIVLYE
LMTGELPYSHINNRDQIIFMVGRGYASPDLSKLYKNCPKAMKRLVADCVKKVKEERPLFP
QILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLTTSPRLPVF
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BDBM50232424 |
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n/a |
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Name | BDBM50232424 |
Synonyms: | CHEMBL4097123 |
Type | Small organic molecule |
Emp. Form. | C27H21F6N3O4 |
Mol. Mass. | 565.4638 |
SMILES | COc1cc2cc(Oc3ccc(NC(=O)Nc4cc(cc(c4)C(F)(F)F)C(F)(F)F)cc3)c(C)nc2cc1OC |
Structure |
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