| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50165047 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304127 (CHEMBL840244) |
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| EC50 | 420±n/a nM |
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| Citation |  McKerrecher, D; Allen, JV; Bowker, SS; Boyd, S; Caulkett, PW; Currie, GS; Davies, CD; Fenwick, ML; Gaskin, H; Grange, E; Hargreaves, RB; Hayter, BR; James, R; Johnson, KM; Johnstone, C; Jones, CD; Lackie, S; Rayner, JW; Walker, RP Discovery, synthesis and biological evaluation of novel glucokinase activators. Bioorg Med Chem Lett15:2103-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50165047 |
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| n/a |
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| Name | BDBM50165047 |
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| Synonyms: | 6-[3-Isopropoxy-5-(3-phenyl-propoxy)-benzoylamino]-nicotinic acid | CHEMBL194137 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26N2O5 |
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| Mol. Mass. | 434.4843 |
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| SMILES | CC(C)Oc1cc(OCCCc2ccccc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O |
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| Structure | 
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