| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50592772 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2205587 (CHEMBL5118295) |
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| IC50 | 30±n/a nM |
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| Citation |  Eissa, AG; Barrow, D; Gee, J; Powell, LE; Foster, PA; Simons, C 4th generation nonsteroidal aromatase inhibitors: An iterative SAR-guided design, synthesis, and biological evaluation towards picomolar dual binding inhibitors. Eur J Med Chem240:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
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| Type: | Enzyme |
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| Mol. Mass.: | 57888.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11511 |
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| Residue: | 503 |
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| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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| BDBM50592772 |
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| n/a |
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| Name | BDBM50592772 |
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| Synonyms: | CHEMBL5175025 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12ClN3O2 |
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| Mol. Mass. | 325.749 |
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| SMILES | Oc1ccc(cc1)C(c1cc2cc(Cl)ccc2o1)n1cncn1 |
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| Structure | 
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