| Reaction Details |
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 | Report a problem with these data |
| Target | Orexin receptor type 2 |
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| Ligand | BDBM50592793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2205645 (CHEMBL5118353) |
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| Ki | 5.4±n/a nM |
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| Citation |  Saitoh, T; Amezawa, M; Horiuchi, J; Nagumo, Y; Yamamoto, N; Kutsumura, N; Ohshita, R; Tokuda, A; Irukayama-Tomobe, Y; Ogawa, Y; Ishikawa, Y; Hasegawa, E; Sakurai, T; Uchida, Y; Sato, T; Gouda, H; Tanimura, R; Yanagisawa, M; Nagase, H Discovery of novel orexin receptor antagonists using a 1,3,5-trioxazatriquinane bearing multiple effective residues (TriMER) library. Eur J Med Chem240:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Orexin receptor type 2 |
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| Name: | Orexin receptor type 2 |
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| Synonyms: | HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R |
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| Type: | Protein |
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| Mol. Mass.: | 50710.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O43614 |
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| Residue: | 444 |
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| Sequence: | MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAG
YIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETW
FFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVS
CIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMV
LAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARR
KTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAAN
PIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKL
SEQVVLTSISTLPAANGAGPLQNW
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| BDBM50592793 |
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| n/a |
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| Name | BDBM50592793 |
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| Synonyms: | CHEMBL5193254 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H33N3O6 |
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| Mol. Mass. | 591.653 |
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| SMILES | [H][C@]12CO[C@]3([H])N1[C@@]([H])(O[C@@]3(C)c1cccc(NC(=O)c3cccc(OC)c3)c1)[C@@](C)(O2)c1cccc(NC(=O)c2ccccc2)c1 |r| |
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| Structure | 
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