| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50165763 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302317 (CHEMBL828905) |
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| Ki | 8.1±n/a nM |
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| Citation |  Puccetti, L; Fasolis, G; Cecchi, A; Winum, JY; Gamberi, A; Montero, JL; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides incorporating thioureido-sulfanilyl scaffolds. Bioorg Med Chem Lett15:2359-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50165763 |
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| n/a |
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| Name | BDBM50165763 |
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| Synonyms: | 4-{4-[2-dimethylaminoethylamino(thioxo)methylamino]phenylsulfonamido}-1-benzenesulfonamide | CHEMBL364081 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H23N5O4S3 |
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| Mol. Mass. | 457.591 |
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| SMILES | CN(C)CCNC(=S)Nc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)S(N)(=O)=O |
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| Structure | 
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