| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50165829 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302988 (CHEMBL830227) |
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| Ki | 11±n/a nM |
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| Citation |  Feng, DM; Wai, JM; Kuduk, SD; Ng, C; Murphy, KL; Ransom, RW; Reiss, D; Chang, RS; Harrell, CM; MacNeil, T; Tang, C; Prueksaritanont, T; Freidinger, RM; Pettibone, DJ; Bock, MG 2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists. Bioorg Med Chem Lett15:2385-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50165829 |
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| n/a |
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| Name | BDBM50165829 |
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| Synonyms: | 4'-{[4-Methyl-3-(3,3,3-trifluoro-propionylamino)-pyridin-2-ylamino]-methyl}-biphenyl-2-carboxylic acid methylamide | CHEMBL196494 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F3N4O2 |
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| Mol. Mass. | 456.4602 |
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| SMILES | CNC(=O)c1ccccc1-c1ccc(CNc2nccc(C)c2NC(=O)CC(F)(F)F)cc1 |
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| Structure | 
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