Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Ligand | BDBM50593124 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2207109 (CHEMBL5119817) | ||
| IC50 | 1700±n/a nM | ||
| Citation |  Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem65:12334-12345 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| N-terminal Xaa-Pro-Lys N-methyltransferase 1 | |||
| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 25382.72 | ||
| Organism: | Homo sapiens | ||
| Description: | ChEMBL_119192 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50593124 | |||
| n/a | |||
| Name | BDBM50593124 | ||
| Synonyms: | CHEMBL5207416 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H24FN3O2S | ||
| Mol. Mass. | 389.487 | ||
| SMILES | CC(C)(NC(=O)O[C@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(F)cc1 |r,wD:7.6,(-.9,2.75,;-.9,1.21,;.43,1.98,;-2.44,1.21,;-3.21,2.54,;-2.44,3.87,;-4.75,2.54,;-5.52,1.21,;-7.06,1.21,;-7.83,-.13,;-7.06,-1.46,;-5.52,-1.46,;-4.75,-.13,;-6.1,.59,;-6.5,-.9,;-.13,-.13,;-.61,-1.59,;.64,-2.5,;1.88,-1.59,;1.41,-.13,;3.37,-1.99,;4.46,-.9,;5.94,-1.3,;6.34,-2.79,;7.83,-3.19,;5.26,-3.87,;3.77,-3.48,)| | ||
| Structure | 
| ||