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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Ligand | BDBM50593127 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2207109 (CHEMBL5119817) | ||
| IC50 | >100000±n/a nM | ||
| Citation |  Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem65:12334-12345 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| N-terminal Xaa-Pro-Lys N-methyltransferase 1 | |||
| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 25382.72 | ||
| Organism: | Homo sapiens | ||
| Description: | ChEMBL_119192 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50593127 | |||
| n/a | |||
| Name | BDBM50593127 | ||
| Synonyms: | CHEMBL5173370 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H23N3O2S | ||
| Mol. Mass. | 309.427 | ||
| SMILES | Cc1nc(cs1)C(C)(C)NC(=O)O[C@@H]1CN2CCC1CC2 |r,wU:13.13,(5.6,-2.68,;4.11,-2.28,;3.64,-.82,;2.1,-.82,;1.62,-2.28,;2.87,-3.19,;1.33,.52,;1.33,2.06,;2.66,1.29,;-.21,.52,;-.98,1.85,;-.21,3.19,;-2.52,1.85,;-3.29,.52,;-4.83,.52,;-5.6,-.82,;-4.83,-2.15,;-3.29,-2.15,;-2.52,-.82,;-3.87,-.1,;-4.27,-1.59,)| | ||
| Structure | 
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