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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Ligand | BDBM50593132 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_2207109 (CHEMBL5119817) | ||
| IC50 | 3200±n/a nM | ||
| Citation |  Dong, G; Deng, Y; Yasgar, A; Yadav, R; Talley, D; Zakharov, AV; Jain, S; Rai, G; Noinaj, N; Simeonov, A; Huang, R Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner. J Med Chem65:12334-12345 (2022) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| N-terminal Xaa-Pro-Lys N-methyltransferase 1 | |||
| Name: | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | ||
| Synonyms: | 2.1.1.244 | Alpha N-terminal protein methyltransferase 1A | C9orf32 | METTL11A | Methyltransferase-like protein 11A | N-terminal RCC1 methyltransferase | N-terminal Xaa-Pro-Lys N-methyltransferase 1 | N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed | NRMT | NRMT1 | NRMT1 | NTM1A | NTM1A_HUMAN | NTMT1 | X-Pro-Lys N-terminal protein methyltransferase 1A | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 25382.72 | ||
| Organism: | Homo sapiens | ||
| Description: | ChEMBL_119192 | ||
| Residue: | 223 | ||
| Sequence: |
| ||
| BDBM50593132 | |||
| n/a | |||
| Name | BDBM50593132 | ||
| Synonyms: | CHEMBL5190365 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H24F3N3O2S | ||
| Mol. Mass. | 439.494 | ||
| SMILES | CC(C)(NC(=O)O[C@@H]1CN2CCC1CC2)c1csc(n1)-c1ccc(cc1)C(F)(F)F |r,wU:7.6,(-1.64,3.15,;-1.64,1.61,;-.31,2.38,;-3.18,1.61,;-3.95,2.94,;-3.18,4.27,;-5.49,2.94,;-6.27,1.61,;-7.81,1.61,;-8.58,.27,;-7.81,-1.06,;-6.27,-1.06,;-5.49,.27,;-6.84,.99,;-7.24,-.5,;-.87,.27,;-1.35,-1.19,;-.1,-2.1,;1.14,-1.19,;.67,.27,;2.63,-1.59,;3.72,-.5,;5.2,-.9,;5.6,-2.39,;4.52,-3.47,;3.03,-3.08,;7.09,-2.79,;8.18,-1.7,;7.49,-4.27,;8.58,-3.19,)| | ||
| Structure | 
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