| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50593147 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2207448 (CHEMBL5120156) |
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| Ki | 24±n/a nM |
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| Citation |  Turgutalp, B; Bhattarai, P; Ercetin, T; Luise, C; Reis, R; Gurdal, EE; Isaak, A; Biriken, D; Dinter, E; Sipahi, H; Schepmann, D; Junker, A; Wünsch, B; Sippl, W; Gulcan, HO; Kizil, C; Yarim, M Discovery of Potent Cholinesterase Inhibition-Based Multi-Target-Directed Lead Compounds for Synaptoprotection in Alzheimer's Disease. J Med Chem65:12292-12318 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein |
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| Type: | Protein |
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| Mol. Mass.: | 25307.17 |
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| Organism: | Cavia porcellus (Guinea pig) |
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| Description: | Q60492 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSK
LIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
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| BDBM50593147 |
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| n/a |
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| Name | BDBM50593147 |
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| Synonyms: | CHEMBL5203777 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H30N4OS |
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| Mol. Mass. | 386.554 |
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| SMILES | Cc1cccc2sc(NC(=O)CCN3CCN(CC3)C3CCCCC3)nc12 |
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| Structure | 
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