| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Bile acid receptor |
|---|
| Ligand | BDBM50167197 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304131 (CHEMBL840248) |
|---|
| EC50 | 94±n/a nM |
|---|
| Citation |  Honorio, KM; Garratt, RC; Andricopulo, AD Hologram quantitative structure-activity relationships for a series of farnesoid X receptor activators. Bioorg Med Chem Lett15:3119-25 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Bile acid receptor |
|---|
| Name: | Bile acid receptor |
|---|
| Synonyms: | BAR | Bile acid receptor FXR | FXR | Farnesol receptor HRR-1 | HRR1 | NR1H4 | NR1H4_HUMAN | Nuclear receptor subfamily 1 group H member 4 | RIP14 | RXR-interacting protein 14 | Retinoid X receptor-interacting protein 14 | farnesoid x receptor |
|---|
| Type: | Nuclear Receptor |
|---|
| Mol. Mass.: | 55916.24 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96RI1 |
|---|
| Residue: | 486 |
|---|
| Sequence: | MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYS
NVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTK
KPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCV
MDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEG
RDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLI
LTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSD
LLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEK
LQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLC
EIWDVQ
|
|
|
|---|
| BDBM50167197 |
|---|
| n/a |
|---|
| Name | BDBM50167197 |
|---|
| Synonyms: | (E)-3-{3-[(3'-Chloro-biphenyl-4-ylmethyl)-cyclohexanecarbonyl-amino]-phenyl}-acrylic acid methyl ester | CHEMBL190844 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H30ClNO3 |
|---|
| Mol. Mass. | 488.017 |
|---|
| SMILES | COC(=O)\C=C\c1cccc(c1)N(Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)C1CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
