Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50167619 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_304826 (CHEMBL827914) |
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IC50 | 198±n/a nM |
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Citation | Noe, MC; Natarajan, V; Snow, SL; Mitchell, PG; Lopresti-Morrow, L; Reeves, LM; Yocum, SA; Carty, TJ; Barberia, JA; Sweeney, FJ; Liras, JL; Vaughn, M; Hardink, JR; Hawkins, JM; Tokar, C Discovery of 3,3-dimethyl-5-hydroxypipecolic hydroxamate-based inhibitors of aggrecanase and MMP-13. Bioorg Med Chem Lett15:2808-11 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50167619 |
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n/a |
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Name | BDBM50167619 |
Synonyms: | (2R,5R)-5-Hydroxy-3,3-dimethyl-1-[4-(4-methyl-benzyloxy)-benzenesulfonyl]-piperidine-2-carboxylic acid hydroxyamide | CHEMBL191359 |
Type | Small organic molecule |
Emp. Form. | C22H28N2O6S |
Mol. Mass. | 448.533 |
SMILES | Cc1ccc(COc2ccc(cc2)S(=O)(=O)N2C[C@H](O)CC(C)(C)[C@@H]2C(=O)NO)cc1 |
Structure |
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