| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor VII |
|---|
| Ligand | BDBM50167836 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_304953 (CHEMBL827832) |
|---|
| IC50 | 12±n/a nM |
|---|
| Citation |  Schweitzer, BA; Neumann, WL; Rahman, HK; Kusturin, CL; Sample, KR; Poda, GI; Kurumbail, RG; Stevens, AM; Stegeman, RA; Stallings, WC; South, MS Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg Med Chem Lett15:3006-11 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor VII |
|---|
| Name: | Coagulation factor VII |
|---|
| Synonyms: | Eptacog alfa | F7 | FA7_HUMAN | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | Thrombin and coagulation factor VII | serum prothrombin conversion accelerator |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51599.89 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 466 |
|---|
| Sequence: | MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
|
|
|
|---|
| BDBM50167836 |
|---|
| n/a |
|---|
| Name | BDBM50167836 |
|---|
| Synonyms: | 3-amino-N-[(2R)-butan-2-yl]-5-(1-{[({4-carbamimidoyl-2-[(2,2,2-trifluoroethyl)carbamoyl]phenyl}methyl)carbamoyl]methyl}-6-oxo-5-(propan-2-ylamino)-1,6-dihydropyrazin-2-yl)benzamide | CHEMBL371558 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H38F3N9O4 |
|---|
| Mol. Mass. | 657.6865 |
|---|
| SMILES | CC[C@@H](C)NC(=O)c1cc(N)cc(c1)-c1cnc(NC(C)C)c(=O)n1CC(=O)NCc1ccc(cc1C(=O)NCC(F)(F)F)C(N)=N |
|---|
| Structure | 
|
|---|
Search and Browse
