| Reaction Details |
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 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Ligand | BDBM50594448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2213042 (CHEMBL5125991) |
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| EC50 | 1093±n/a nM |
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| Citation |  Gehrtz, P; Marom, S; Bührmann, M; Hardick, J; Kleinbölting, S; Shraga, A; Dubiella, C; Gabizon, R; Wiese, JN; Müller, MP; Cohen, G; Babaev, I; Shurrush, K; Avram, L; Resnick, E; Barr, H; Rauh, D; London, N Optimization of Covalent MKK7 Inhibitors J Med Chem65:10341-10356 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dual specificity mitogen-activated protein kinase kinase 7 |
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| Name: | Dual specificity mitogen-activated protein kinase kinase 7 |
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| Synonyms: | Dual specificity mitogen-activated protein kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) | JNKK2 | MAP2K7 | MEK7 | MKK7 | MP2K7_HUMAN | PRKMK7 | SKK4 |
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| Type: | Protein |
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| Mol. Mass.: | 47502.52 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14733 |
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| Residue: | 419 |
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| Sequence: | MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSES
SPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEIMKQTGYLTIGGQRYQAEINDL
ENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMRRSGNKEENKRILMDLDVVLKSHDCPYIV
QCFGTFITNTDVFIAMELMGTCAEKLKKRMQGPIPERILGKMTVAIVKALYYLKEKHGVI
HRDVKPSNILLDERGQIKLCDFGISGRLVDSKAKTRSAGCAAYMAPERIDPPDPTKPDYD
IRADVWSLGISLVELATGQFPYKNCKTDFEVLTKVLQEEPPLLPGHMGFSGDFQSFVKDC
LTKDHRKRPKYNKLLEHSFIKRYETLEVDVASWFKDVMAKTESPRTSGVLSQPHLPFFR
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| BDBM50594448 |
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| n/a |
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| Name | BDBM50594448 |
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| Synonyms: | CHEMBL5203494 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20ClN9O2 |
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| Mol. Mass. | 465.896 |
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| SMILES | Nc1ncnc2n(nc(-c3cn(nn3)-c3ccc(Cl)cc3O)c12)[C@@H]1CCCN(C1)C(=O)C=C |r| |
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| Structure | 
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