Reaction Details |
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Target | Growth factor receptor-bound protein 2 |
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Ligand | BDBM50168317 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_305462 (CHEMBL830958) |
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IC50 | 8.4±n/a nM |
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Citation | Kang, SU; Shi, ZD; Worthy, KM; Bindu, LK; Dharmawardana, PG; Choyke, SJ; Bottaro, DP; Fisher, RJ; Burke, TR Examination of phosphoryl-mimicking functionalities within a macrocyclic Grb2 SH2 domain-binding platform. J Med Chem48:3945-8 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Growth factor receptor-bound protein 2 |
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Name: | Growth factor receptor-bound protein 2 |
Synonyms: | ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2 |
Type: | Protein |
Mol. Mass.: | 25205.04 |
Organism: | Homo sapiens (Human) |
Description: | P62993 |
Residue: | 217 |
Sequence: | MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPW
FFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL
WVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRG
DFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
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BDBM50168317 |
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n/a |
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Name | BDBM50168317 |
Synonyms: | CHEMBL193281 | [(15R,20S)-10-[4-(Benzyl-hydroxy-phosphinoylmethyl)-phenyl]-18-carbamoylmethyl-14-(5-methyl-indol-1-ylmethyl)-20-oxo-8,17-di(S)-oxo-7,16,19-triaza-spiro[5.14]icos-11-en-9-yl]-acetic acid |
Type | Small organic molecule |
Emp. Form. | C45H54N5O8P |
Mol. Mass. | 823.9127 |
SMILES | Cc1ccc2n(C[C@H]3CNC(=O)[C@H](CC(N)=O)NC(=O)C4(CCCCC4)NC(=O)[C@@H](CC(O)=O)[C@H](\C=C\C3)c3ccc(CP(O)(=O)Cc4ccccc4)cc3)ccc2c1 |t:36| |
Structure |
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