| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Estrogen receptor beta |
|---|
| Ligand | BDBM50168352 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_306229 (CHEMBL831137) |
|---|
| IC50 | 1.2±n/a nM |
|---|
| Citation |  Mewshaw, RE; Edsall, RJ; Yang, C; Manas, ES; Xu, ZB; Henderson, RA; Keith, JC; Harris, HA ERbeta ligands. 3. Exploiting two binding orientations of the 2-phenylnaphthalene scaffold to achieve ERbeta selectivity. J Med Chem48:3953-79 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Estrogen receptor beta |
|---|
| Name: | Estrogen receptor beta |
|---|
| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 59238.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q92731 |
|---|
| Residue: | 530 |
|---|
| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
|
|
|
|---|
| BDBM50168352 |
|---|
| n/a |
|---|
| Name | BDBM50168352 |
|---|
| Synonyms: | 4-Ethynyl-6-(3-fluoro-4-hydroxy-phenyl)-naphthalen-2-ol | CHEMBL191759 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H11FO2 |
|---|
| Mol. Mass. | 278.2771 |
|---|
| SMILES | Oc1cc(C#C)c2cc(ccc2c1)-c1ccc(O)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
