| Reaction Details |
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 | Report a problem with these data |
| Target | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Ligand | BDBM50168758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304668 (CHEMBL827868) |
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| IC50 | 1.7±n/a nM |
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| Citation |  Noe, MC; Natarajan, V; Snow, SL; Wolf-Gouveia, LA; Mitchell, PG; Lopresti-Morrow, L; Reeves, LM; Yocum, SA; Otterness, I; Bliven, MA; Carty, TJ; Barberia, JT; Sweeney, FJ; Liras, JL; Vaughn, M Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13. Bioorg Med Chem Lett15:3385-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Disintegrin and metalloproteinase domain-containing protein 17 |
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| Name: | Disintegrin and metalloproteinase domain-containing protein 17 |
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| Synonyms: | ADA17_RAT | ADAM 17 | Adam17 | CD_antigen=CD156b | Disintegrin and metalloproteinase domain-containing protein 17 | Tace |
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| Type: | PROTEIN |
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| Mol. Mass.: | 93005.00 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_304668 |
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| Residue: | 827 |
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| Sequence: | MRQRLLFLTTLVPFVLAPRPPEEPGSGSHLRLEKLDSLLSDYDILSLSNIQQHSIRKRDL
QSATHLETLLTFSALKRHFKLYLTSSTERFSQNLRVVVVDGKEESEYSVKWQDFFSGHVV
GEPDSRVLAHIGDDDVTVRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKDFSRLQS
PKVCGYLNADSEELLPKGLIDREPSEEFVRRVKRRAEPNPLKNTCKLLVVADHRFYKYMG
RGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGVQIEQIRILKSPQEVKPGERHFNM
AKSFPNEEKDAWDVKMLLEQFSLDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANS
HGGVCPKAYYNPGVKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGN
SRVDEGEECDPGIMYLNNDTCCNSDCTLKPGVQCSDRNSPCCKNCQFETAQKKCQEAINA
TCKGVSYCTGNSSECPPPGDAEDDTVCLDLGKCKAGKCIPFCKREQELESCACADTDNSC
KVCCRNLSGPCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLS
INTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHHSNIEMLSSMD
SASVRIIKPFPAPQTPGRLQALQPAAMMPPVSAAPKLDHQRMDTIQEDPSTDSHVDDDGF
EKDPFPNSSAAAKSFEDLTDHPVTRSEKAASFKLQRQSRVDSKETEC
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| BDBM50168758 |
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| n/a |
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| Name | BDBM50168758 |
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| Synonyms: | (2R,3S)-3-Ethyl-1-[4-(4-fluoro-benzyloxy)-benzenesulfonyl]-3-hydroxy-piperidine-2-carboxylic acid hydroxyamide | CHEMBL435102 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25FN2O6S |
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| Mol. Mass. | 452.496 |
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| SMILES | CC[C@]1(O)CCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCc2ccc(F)cc2)cc1 |
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| Structure | 
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