| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Polycomb protein EED |
|---|
| Ligand | BDBM291687 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_2214723 (CHEMBL5127855) |
|---|
| IC50 | 60±n/a nM |
|---|
| Citation |  Zhao, Y; Guan, YY; Zhao, F; Yu, T; Zhang, SJ; Zhang, YZ; Duan, YC; Zhou, XL Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs. Eur J Med Chem231:0 (2022) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Polycomb protein EED |
|---|
| Name: | Polycomb protein EED |
|---|
| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 50201.68 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | O75530 |
|---|
| Residue: | 441 |
|---|
| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
|
|
|
|---|
| BDBM291687 |
|---|
| n/a |
|---|
| Name | BDBM291687 |
|---|
| Synonyms: | N-((5-Fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine | US11207325, Example 2 | US9580437, Example 2 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H17FN6O |
|---|
| Mol. Mass. | 376.387 |
|---|
| SMILES | Cc1ncccc1-c1cnc(NCc2c3CCOc3ccc2F)n2cnnc12 |
|---|
| Structure | 
|
|---|
Search and Browse
