| Reaction Details |
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 | Report a problem with these data |
| Target | Polycomb protein EED |
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| Ligand | BDBM50594938 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2214724 (CHEMBL5127856) |
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| IC50 | 4.5±n/a nM |
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| Citation |  Zhao, Y; Guan, YY; Zhao, F; Yu, T; Zhang, SJ; Zhang, YZ; Duan, YC; Zhou, XL Recent strategies targeting Embryonic Ectoderm Development (EED) for cancer therapy: Allosteric inhibitors, PPI inhibitors, and PROTACs. Eur J Med Chem231:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polycomb protein EED |
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| Name: | Polycomb protein EED |
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| Synonyms: | EED | EED_HUMAN | WAIT-1 | WD protein associating with integrin cytoplasmic tails 1 | hEED |
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| Type: | Protein |
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| Mol. Mass.: | 50201.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O75530 |
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| Residue: | 441 |
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| Sequence: | MSEREVSTAPAGTDMPAAKKQKLSSDENSNPDLSGDENDDAVSIESGTNTERPDTPTNTP
NAPGRKSWGKGKWKSKKCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNR
VTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITM
QCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVL
SADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFS
TRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQ
CDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSR
DSSILIAVCDDASIWRWDRLR
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| BDBM50594938 |
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| n/a |
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| Name | BDBM50594938 |
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| Synonyms: | CHEMBL5201204 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19FN4O2 |
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| Mol. Mass. | 368.4012 |
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| SMILES | [2H]C([2H])(Nc1ncc(-c2cccnc2C)c(=O)n1C)c1c2CCOc2ccc1F |
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| Structure | 
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