| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase |
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| Ligand | BDBM50169658 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_311781 (CHEMBL826403) |
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| IC50 | 76±n/a nM |
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| Citation |  Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett15:3732-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase |
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| Name: | Methionine aminopeptidase |
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| Synonyms: | EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map |
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| Type: | Enzyme |
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| Mol. Mass.: | 29326.96 |
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| Organism: | Escherichia coli (strain K12) |
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| Description: | Full-length untagged EcMAP was expressed in E. coli. |
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| Residue: | 264 |
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| Sequence: | MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACL
GYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTI
MGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEE
PQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVV
TDNGCEILTLRKDDTIPAIISHDE
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| BDBM50169658 |
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| n/a |
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| Name | BDBM50169658 |
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| Synonyms: | 5-(2-Fluoro-benzoylamino)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL361155 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9FN4O2S2 |
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| Mol. Mass. | 348.375 |
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| SMILES | Fc1ccccc1C(=O)Nc1scnc1C(=O)Nc1nccs1 |
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| Structure | 
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