| Reaction Details |
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 | Report a problem with these data |
| Target | Methionine aminopeptidase 1 |
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| Ligand | BDBM50169675 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_311969 (CHEMBL834386) |
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| IC50 | 860.0±n/a nM |
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| Citation |  Cui, YM; Huang, QQ; Xu, J; Chen, LL; Li, JY; Ye, QZ; Li, J; Nan, FJ Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives. Bioorg Med Chem Lett15:3732-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Methionine aminopeptidase 1 |
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| Name: | Methionine aminopeptidase 1 |
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| Synonyms: | MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43382.92 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_10701 |
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| Residue: | 387 |
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| Sequence: | MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYK
AHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQR
NDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYP
SPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGEN
ISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFF
HCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHT
LLVTEHGVEILTARNKKSPGGPRQRIK
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| BDBM50169675 |
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| n/a |
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| Name | BDBM50169675 |
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| Synonyms: | 5-(2-Pyrrolidin-1-yl-acetylamino)-thiazole-4-carboxylic acid thiazol-2-ylamide | CHEMBL178249 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15N5O2S2 |
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| Mol. Mass. | 337.421 |
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| SMILES | O=C(CN1CCCC1)Nc1scnc1C(=O)Nc1nccs1 |
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| Structure | 
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