| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50170148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_306441 (CHEMBL829085) |
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| IC50 | >100000±n/a nM |
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| Citation |  Normand-Bayle, M; Bénard, C; Zouhiri, F; Mouscadet, JF; Leh, H; Thomas, CM; Mbemba, G; Desmaële, D; d'Angelo, J New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: synthesis and biological activity. Bioorg Med Chem Lett15:4019-22 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50170148 |
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| n/a |
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| Name | BDBM50170148 |
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| Synonyms: | CHEMBL188712 | {2-[(E)-2-(3,4-Dihydroxy-phenyl)-vinyl]-8-hydroxy-quinolin-7-yl}-(4-hydroxy-phenyl)-methanone |
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| Type | Small organic molecule |
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| Emp. Form. | C24H17NO5 |
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| Mol. Mass. | 399.3955 |
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| SMILES | Oc1ccc(cc1)C(=O)c1ccc2ccc(\C=C\c3ccc(O)c(O)c3)nc2c1O |
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| Structure | 
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