Reaction Details |
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Target | Sodium-dependent serotonin transporter |
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Ligand | BDBM50170624 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302542 (CHEMBL827393) |
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Ki | >1000±n/a nM |
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Citation | Palani, A; Shapiro, S; McBriar, MD; Clader, JW; Greenlee, WJ; Spar, B; Kowalski, TJ; Farley, C; Cook, J; van Heek, M; Weig, B; O'neill, K; Graziano, M; Hawes, B Biaryl ureas as potent and orally efficacious melanin concentrating hormone receptor 1 antagonists for the treatment of obesity. J Med Chem48:4746-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent serotonin transporter |
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Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
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BDBM50170624 |
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n/a |
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Name | BDBM50170624 |
Synonyms: | 1-(3'-Cyano-biphenyl-4-yl)-3-(3-fluoro-4-trifluoromethyl-phenyl)-1-[2-(4-methyl-piperazin-1-yl)-ethyl]-urea | CHEMBL187996 |
Type | Small organic molecule |
Emp. Form. | C28H27F4N5O |
Mol. Mass. | 525.5405 |
SMILES | CN1CCN(CCN(C(=O)Nc2ccc(c(F)c2)C(F)(F)F)c2ccc(cc2)-c2cccc(c2)C#N)CC1 |
Structure |
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