Reaction Details |
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Target | Tyrosine-protein phosphatase non-receptor type 1 |
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Ligand | BDBM50171117 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_320956 (CHEMBL885363) |
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Ki | 13±n/a nM |
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Citation | Holmes, CP; Li, X; Pan, Y; Xu, C; Bhandari, A; Moody, CM; Miguel, JA; Ferla, SW; De Francisco, MN; Frederick, BT; Zhou, S; Macher, N; Jang, L; Irvine, JD; Grove, JR Discovery and structure-activity relationships of novel sulfonamides as potent PTP1B inhibitors. Bioorg Med Chem Lett15:4336-41 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein phosphatase non-receptor type 1 |
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Name: | Tyrosine-protein phosphatase non-receptor type 1 |
Synonyms: | PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B) |
Type: | Protein phosphatase |
Mol. Mass.: | 49963.76 |
Organism: | Homo sapiens (Human) |
Description: | Human recombinant GST-fusion PTP1B (1-435). |
Residue: | 435 |
Sequence: | MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLE
PPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYG
IESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLT
AGAYLCYRFLFNSNT
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BDBM50171117 |
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n/a |
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Name | BDBM50171117 |
Synonyms: | 2-(4-(N-(3-bromo-4-(difluoro(phosphono)methyl)benzyl)-N-(4-(N,N-dimethylsulfamoyl)benzyl)sulfamoyl)phenoxy)acetic acid | CHEMBL198940 | {4-[[3-Bromo-4-(difluoro-phosphono-methyl)-benzyl]-(4-dimethylsulfamoyl-benzyl)-sulfamoyl]-phenoxy}-acetic acid |
Type | Small organic molecule |
Emp. Form. | C25H26BrF2N2O10PS2 |
Mol. Mass. | 727.486 |
SMILES | CN(C)S(=O)(=O)c1ccc(CN(Cc2ccc(c(Br)c2)C(F)(F)P(O)(O)=O)S(=O)(=O)c2ccc(OCC(O)=O)cc2)cc1 |
Structure |
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