| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase 2 |
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| Ligand | BDBM50446130 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2218813 (CHEMBL5132147) |
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| IC50 | 0.500000±n/a nM |
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| Citation |  Yu, J; Luo, L; Hu, T; Cui, Y; Sun, X; Gou, W; Hou, W; Li, Y; Sun, T Structure-based design, synthesis, and evaluation of inhibitors with high selectivity for PARP-1 over PARP-2. Eur J Med Chem227:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase 2 |
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| Name: | Poly [ADP-ribose] polymerase 2 |
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| Synonyms: | (ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 66225.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9UGN5 |
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| Residue: | 583 |
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| Sequence: | MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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| BDBM50446130 |
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| n/a |
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| Name | BDBM50446130 |
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| Synonyms: | AG-014699 | AG-14447 | RUCAPARIB CAMSYLATE | Rucaparib |
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| Type | Small organic molecule |
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| Emp. Form. | C19H18FN3O |
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| Mol. Mass. | 323.3641 |
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| SMILES | CNCc1ccc(cc1)-c1[nH]c2cc(F)cc3C(=O)NCCc1c23 |
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| Structure | 
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