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TargetMuscarinic acetylcholine receptor M4
LigandBDBM50596229
Substrate/Competitorn/a
Meas. Tech.ChEMBL_2219875 (CHEMBL5133209)
IC50 12±n/a nM
Citation Bender, AMCarter, TRSpock, MRodriguez, ALDickerson, JWRook, JMChang, SQi, APresley, CCEngers, DWHarp, JMBridges, TMNiswender, CMConn, PJLindsley, CW Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M Bioorg Med Chem Lett56:0 (2022) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M4
Name:Muscarinic acetylcholine receptor M4
Synonyms:ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:Enzyme Catalytic Domain
Mol. Mass.:53079.31
Organism:Homo sapiens (Human)
Description:Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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  Blast E-value cutoff:
BDBM50596229
n/a
NameBDBM50596229
Synonyms:CHEMBL5205163
TypeSmall organic molecule
Emp. Form.C25H32ClFN4
Mol. Mass.443
SMILESFc1ccc(Cl)c(c1)-c1ccc(NC[C@@H]2CC22CCN(CC3CCCCC3)CC2)nn1 |r|
Structure
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