| Reaction Details |
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 | Report a problem with these data |
| Target | Pyruvate kinase PKLR |
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| Ligand | BDBM50596758 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2222229 (CHEMBL5135563) |
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| IC50 | 4100±n/a nM |
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| Citation |  Nain-Perez, A; Foller Füchtbauer, A; Hĺversen, L; Lulla, A; Gao, C; Matic, J; Monjas, L; Rodríguez, A; Brear, P; Kim, W; Hyvönen, M; Borén, J; Mardinoglu, A; Uhlen, M; Grřtli, M Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase. Eur J Med Chem234:0 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pyruvate kinase PKLR |
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| Name: | Pyruvate kinase PKLR |
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| Synonyms: | KPYR_HUMAN | PK1 | PK1 | PKL | PKLR | Pyruvate kinase 1 | Pyruvate kinase PKLR | Pyruvate kinase isozymes L/R | R-type/L-type pyruvate kinase | Red cell/liver pyruvate kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61835.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_103054 |
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| Residue: | 574 |
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| Sequence: | MSIQENISSLQLRSWVSKSQRDLAKSILIGAPGGPAGYLRRASVAQLTQELGTAFFQQQQ
LPAAMADTFLEHLCLLDIDSEPVAARSTSIIATIGPASRSVERLKEMIKAGMNIARLNFS
HGSHEYHAESIANVREAVESFAGSPLSYRPVAIALDTKGPEIRTGILQGGPESEVELVKG
SQVLVTVDPAFRTRGNANTVWVDYPNIVRVVPVGGRIYIDDGLISLVVQKIGPEGLVTQV
ENGGVLGSRKGVNLPGAQVDLPGLSEQDVRDLRFGVEHGVDIVFASFVRKASDVAAVRAA
LGPEGHGIKIISKIENHEGVKRFDEILEVSDGIMVARGDLGIEIPAEKVFLAQKMMIGRC
NLAGKPVVCATQMLESMITKPRPTRAETSDVANAVLDGADCIMLSGETAKGNFPVEAVKM
QHAIAREAEAAVYHRQLFEELRRAAPLSRDPTEVTAIGAVEAAFKCCAAAIIVLTTTGRS
AQLLSRYRPRAAVIAVTRSAQAARQVHLCRGVFPLLYREPPEAIWADDVDRRVQFGIESG
KLRGFLRVGDLVIVVTGWRPGSGYTNIMRVLSIS
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| BDBM50596758 |
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| n/a |
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| Name | BDBM50596758 |
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| Synonyms: | CHEMBL5172724 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N2O9S |
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| Mol. Mass. | 434.377 |
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| SMILES | OC(=O)CNC(=O)CNS(=O)(=O)c1cc2C(=O)c3ccccc3C(=O)c2c(O)c1O |
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| Structure | 
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