| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50173404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321362 (CHEMBL881506) |
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| IC50 | 2.4±n/a nM |
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| Citation |  Black, WC; Bayly, CI; Davis, DE; Desmarais, S; Falgueyret, JP; Léger, S; Li, CS; Massé, F; McKay, DJ; Palmer, JT; Percival, MD; Robichaud, J; Tsou, N; Zamboni, R Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. Bioorg Med Chem Lett15:4741-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50173404 |
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| n/a |
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| Name | BDBM50173404 |
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| Synonyms: | (S)-2-[1-(4-Bromo-phenyl)-2,2,3,3,3-pentafluoro-propylamino]-4-methyl-pentanoic acid cyanomethyl-amide | CHEMBL372046 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H19BrF5N3O |
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| Mol. Mass. | 456.248 |
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| SMILES | CC(C)C[C@H](NC(c1ccc(Br)cc1)C(F)(F)C(F)(F)F)C(=O)NCC#N |
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| Structure | 
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