| Reaction Details |
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 | Report a problem with these data |
| Target | Procathepsin L |
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| Ligand | BDBM19854 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321237 (CHEMBL881772) |
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| IC50 | 3903±n/a nM |
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| Citation |  Black, WC; Bayly, CI; Davis, DE; Desmarais, S; Falgueyret, JP; Léger, S; Li, CS; Massé, F; McKay, DJ; Palmer, JT; Percival, MD; Robichaud, J; Tsou, N; Zamboni, R Trifluoroethylamines as amide isosteres in inhibitors of cathepsin K. Bioorg Med Chem Lett15:4741-4 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Procathepsin L |
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| Name: | Procathepsin L |
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| Synonyms: | CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein |
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| Type: | Enzyme |
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| Mol. Mass.: | 37557.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purchased from Calbiochem (San Diego, CA). |
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| Residue: | 333 |
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| Sequence: | MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
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| BDBM19854 |
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| n/a |
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| Name | BDBM19854 |
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| Synonyms: | CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(4-methylpiperazin-1-yl)-1,3-thiazol-4-yl]benzamide | basic piperazine-containing compound, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H30N6O2S |
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| Mol. Mass. | 466.599 |
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| SMILES | CN1CCN(CC1)c1nc(cs1)-c1ccc(cc1)C(=O)NC1(CCCCC1)C(=O)NCC#N |
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| Structure | 
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