| Reaction Details |
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 | Report a problem with these data |
| Target | Excitatory amino acid transporter 1 |
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| Ligand | BDBM50410464 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321548 (CHEMBL881962) |
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| IC50 | 200±n/a nM |
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| Citation |  Greenfield, A; Grosanu, C; Dunlop, J; McIlvain, B; Carrick, T; Jow, B; Lu, Q; Kowal, D; Williams, J; Butera, J Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2. Bioorg Med Chem Lett15:4985-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Excitatory amino acid transporter 1 |
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| Name: | Excitatory amino acid transporter 1 |
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| Synonyms: | EAA1_HUMAN | EAAT1 | Excitatory Amino Acid EAAT1 | GLAST | GLAST1 | SLC1A3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 59577.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Excitatory Amino Acid EAAT1 0 HUMAN::P43003 |
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| Residue: | 542 |
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| Sequence: | MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIV
GTILGFTLRPYRMSYREVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKASGKMG
MRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDLIRNMFPP
NLVEACFKQFKTNYEKRSFKVPIQANETLVGAVINNVSEAMETLTRITEELVPVPGSVNG
VNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNEAIMRLVAVIMWYAPVGILFLIAGK
IVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQALITAL
GTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE
LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRT
TTNVLGDSLGAGIVEHLSRHELKNRDVEMGNSVIEENEMKKPYQLIAQDNETEKPIDSET
KM
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| BDBM50410464 |
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| n/a |
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| Name | BDBM50410464 |
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| Synonyms: | CHEMBL2113111 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18ClFN2O3 |
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| Mol. Mass. | 364.799 |
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| SMILES | CCc1cc(ccc1NC(=O)C[C@H](N)C(O)=O)-c1ccc(F)c(Cl)c1 |r| |
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| Structure | 
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