Found 276 hits with Last Name = 'butera' and Initial = 'j' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314557
((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cnccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9O3/c38-28(24-19-29-9-10-30-24)35-15-13-34(14-16-35)11-4-8-31-27-23-18-21-6-1-2-12-36(21)26(23)25(32-33-27)20-5-3-7-22(17-20)37(39)40/h1-3,5-7,9-10,12,17-19H,4,8,11,13-16H2,(H,31,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314558
((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314583
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cnccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C26H29N9O3/c1-18-15-21-24(32(18)2)23(19-5-3-6-20(16-19)35(37)38)30-31-25(21)29-7-4-10-33-11-13-34(14-12-33)26(36)22-17-27-8-9-28-22/h3,5-6,8-9,15-17H,4,7,10-14H2,1-2H3,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 77 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 2
(Homo sapiens (Human)) | BDBM86712
(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)Show SMILES N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r| Show InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| 85 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Excitatory amino acid transporter 2
(Homo sapiens (Human)) | BDBM86713
(WAY 213394 | WAY-213394)Show InChI InChI=1S/C17H18N2O3/c1-11-4-2-3-5-14(11)12-6-8-13(9-7-12)19-16(20)10-15(18)17(21)22/h2-9,15H,10,18H2,1H3,(H,19,20)(H,21,22)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 145 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314557
((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cnccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9O3/c38-28(24-19-29-9-10-30-24)35-15-13-34(14-16-35)11-4-8-31-27-23-18-21-6-1-2-12-36(21)26(23)25(32-33-27)20-5-3-7-22(17-20)37(39)40/h1-3,5-7,9-10,12,17-19H,4,8,11,13-16H2,(H,31,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 147 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 2
(Homo sapiens (Human)) | BDBM86714
(WAY 212922 | WAY-212922)Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 157 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 2
(Homo sapiens (Human)) | BDBM86711
(3-[3-Methyl-4-(4-chlorophenyl)benzoylamino]alanine...)Show SMILES Cc1cc(ccc1-c1ccc(Cl)cc1)C(=O)NC[C@H](N)C(O)=O Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-12(16(21)20-9-15(19)17(22)23)4-7-14(10)11-2-5-13(18)6-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314564
(4-(3-nitrophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazi...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27N9O2/c37-36(38)22-8-3-6-20(18-22)24-25-23(19-21-7-1-2-13-35(21)25)26(32-31-24)28-11-5-12-33-14-16-34(17-15-33)27-29-9-4-10-30-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 210 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314581
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cncs3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C25H28N8O3S/c1-17-13-20-23(30(17)2)22(18-5-3-6-19(14-18)33(35)36)28-29-24(20)27-7-4-8-31-9-11-32(12-10-31)25(34)21-15-26-16-37-21/h3,5-6,13-16H,4,7-12H2,1-2H3,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 222 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314578
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ccccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C27H30N8O3/c1-19-17-22-25(32(19)2)24(20-7-5-8-21(18-20)35(37)38)30-31-26(22)29-11-6-12-33-13-15-34(16-14-33)27(36)23-9-3-4-10-28-23/h3-5,7-10,17-18H,6,11-16H2,1-2H3,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 238 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314571
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H28FN7O/c30-22-8-5-7-21(19-22)26-27-24(20-23-9-2-4-14-37(23)27)28(34-33-26)32-12-6-13-35-15-17-36(18-16-35)29(38)25-10-1-3-11-31-25/h1-5,7-11,14,19-20H,6,12-13,15-18H2,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 241 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314570
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cccnc2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H28FN7O/c30-23-8-3-6-21(18-23)26-27-25(19-24-9-1-2-13-37(24)27)28(34-33-26)32-11-5-12-35-14-16-36(17-15-35)29(38)22-7-4-10-31-20-22/h1-4,6-10,13,18-20H,5,11-12,14-17H2,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 413 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314577
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cccnc3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C27H30N8O3/c1-19-16-23-25(32(19)2)24(20-6-3-8-22(17-20)35(37)38)30-31-26(23)29-10-5-11-33-12-14-34(15-13-33)27(36)21-7-4-9-28-18-21/h3-4,6-9,16-18H,5,10-15H2,1-2H3,(H,29,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 432 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314580
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3c[s+]n[n-]3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C24H27N9O3S/c1-16-13-19-22(30(16)2)21(17-5-3-6-18(14-17)33(35)36)27-28-23(19)25-7-4-8-31-9-11-32(12-10-31)24(34)20-15-37-29-26-20/h3,5-6,13-15H,4,7-12H2,1-2H3,(H-,25,26,28,29,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 977 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314575
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ncccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C26H29N9O3/c1-18-16-21-23(32(18)2)22(19-6-3-7-20(17-19)35(37)38)30-31-24(21)27-10-5-11-33-12-14-34(15-13-33)26(36)25-28-8-4-9-29-25/h3-4,6-9,16-17H,5,10-15H2,1-2H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314563
(3-(1-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propylam...)Show SMILES N#Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9/c29-20-21-6-3-7-22(18-21)25-26-24(19-23-8-1-2-13-37(23)26)27(34-33-25)30-11-5-12-35-14-16-36(17-15-35)28-31-9-4-10-32-28/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,30,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314560
(4-(3-bromophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazi...)Show SMILES Brc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27BrN8/c28-21-7-3-6-20(18-21)24-25-23(19-22-8-1-2-13-36(22)25)26(33-32-24)29-11-5-12-34-14-16-35(17-15-34)27-30-9-4-10-31-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 3
(Homo sapiens (Human)) | BDBM86711
(3-[3-Methyl-4-(4-chlorophenyl)benzoylamino]alanine...)Show SMILES Cc1cc(ccc1-c1ccc(Cl)cc1)C(=O)NC[C@H](N)C(O)=O Show InChI InChI=1S/C17H17ClN2O3/c1-10-8-12(16(21)20-9-15(19)17(22)23)4-7-14(10)11-2-5-13(18)6-3-11/h2-8,15H,9,19H2,1H3,(H,20,21)(H,22,23)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 3
(Homo sapiens (Human)) | BDBM86714
(WAY 212922 | WAY-212922)Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314565
(1-(4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indoli...)Show SMILES CC(=O)N1CCN(CCCNc2nnc(-c3cccc(F)c3)c3c2cc2ccccn32)CC1 Show InChI InChI=1S/C25H27FN6O/c1-18(33)31-14-12-30(13-15-31)10-5-9-27-25-22-17-21-8-2-3-11-32(21)24(22)23(28-29-25)19-6-4-7-20(26)16-19/h2-4,6-8,11,16-17H,5,9-10,12-15H2,1H3,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 1
(Homo sapiens (Human)) | BDBM86713
(WAY 213394 | WAY-213394)Show InChI InChI=1S/C17H18N2O3/c1-11-4-2-3-5-14(11)12-6-8-13(9-7-12)19-16(20)10-15(18)17(21)22/h2-9,15H,10,18H2,1H3,(H,19,20)(H,21,22)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 1.97E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314561
(4-(3-chlorophenyl)-N-(3-(4-(pyrimidin-2-yl)piperaz...)Show SMILES Clc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27ClN8/c28-21-7-3-6-20(18-21)24-25-23(19-22-8-1-2-13-36(22)25)26(33-32-24)29-11-5-12-34-14-16-35(17-15-34)27-30-9-4-10-31-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314564
(4-(3-nitrophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazi...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27N9O2/c37-36(38)22-8-3-6-20(18-22)24-25-23(19-21-7-1-2-13-35(21)25)26(32-31-24)28-11-5-12-33-14-16-34(17-15-33)27-29-9-4-10-30-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,28,32) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314556
(4-phenyl-N-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)pr...)Show SMILES C(CNc1nnc(-c2ccccc2)c2c1cc1ccccn21)CN1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C27H28N8/c1-2-8-21(9-3-1)24-25-23(20-22-10-4-5-15-35(22)25)26(32-31-24)28-13-7-14-33-16-18-34(19-17-33)27-29-11-6-12-30-27/h1-6,8-12,15,20H,7,13-14,16-19H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314568
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccc2)c2cc3ccccn3c12 Show InChI InChI=1S/C30H29FN6O/c31-24-11-6-10-23(20-24)27-28-26(21-25-12-4-5-15-37(25)28)29(34-33-27)32-13-7-14-35-16-18-36(19-17-35)30(38)22-8-2-1-3-9-22/h1-6,8-12,15,20-21H,7,13-14,16-19H2,(H,32,34) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314562
(4-(3-fluorophenyl)-N-(3-(4-(pyrimidin-2-yl)piperaz...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27FN8/c28-21-7-3-6-20(18-21)24-25-23(19-22-8-1-2-13-36(22)25)26(33-32-24)29-11-5-12-34-14-16-35(17-15-34)27-30-9-4-10-31-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314563
(3-(1-(3-(4-(pyrimidin-2-yl)piperazin-1-yl)propylam...)Show SMILES N#Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9/c29-20-21-6-3-7-22(18-21)25-26-24(19-23-8-1-2-13-37(23)26)27(34-33-25)30-11-5-12-35-14-16-36(17-15-35)28-31-9-4-10-32-28/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,30,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 3.35E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 1
(Homo sapiens (Human)) | BDBM86714
(WAY 212922 | WAY-212922)Show SMILES N[C@@H](CC(=O)Nc1ccc-2c(Cc3cc(ccc-23)C(F)(F)F)c1)C(O)=O Show InChI InChI=1S/C18H15F3N2O3/c19-18(20,21)11-1-3-13-9(6-11)5-10-7-12(2-4-14(10)13)23-16(24)8-15(22)17(25)26/h1-4,6-7,15H,5,8,22H2,(H,23,24)(H,25,26)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 3.43E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 3
(Homo sapiens (Human)) | BDBM86712
(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)Show SMILES N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r| Show InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 3.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314559
(CHEMBL1091807 | N-(3-(4-(pyrimidin-2-yl)piperazin-...)Show SMILES Cc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H30N8/c1-21-7-4-8-22(19-21)25-26-24(20-23-9-2-3-14-36(23)26)27(33-32-25)29-12-6-13-34-15-17-35(18-16-34)28-30-10-5-11-31-28/h2-5,7-11,14,19-20H,6,12-13,15-18H2,1H3,(H,29,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314574
((4-(3-(7-(3-fluorophenyl)-1,2-dimethyl-1H-pyrrolo[...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ncccn3)nnc(-c3cccc(F)c3)c2n1C Show InChI InChI=1S/C26H29FN8O/c1-18-16-21-23(33(18)2)22(19-6-3-7-20(27)17-19)31-32-24(21)28-10-5-11-34-12-14-35(15-13-34)26(36)25-29-8-4-9-30-25/h3-4,6-9,16-17H,5,10-15H2,1-2H3,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314583
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cnccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C26H29N9O3/c1-18-15-21-24(32(18)2)23(19-5-3-6-20(16-19)35(37)38)30-31-25(21)29-7-4-10-33-11-13-34(14-12-33)26(36)22-17-27-8-9-28-22/h3,5-6,8-9,15-17H,4,7,10-14H2,1-2H3,(H,29,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314582
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ccnnc3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C26H29N9O3/c1-18-15-22-24(32(18)2)23(19-5-3-6-21(16-19)35(37)38)30-31-25(22)27-8-4-10-33-11-13-34(14-12-33)26(36)20-7-9-28-29-17-20/h3,5-7,9,15-17H,4,8,10-14H2,1-2H3,(H,27,31) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314566
(1-(4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indoli...)Show SMILES CCC(=O)N1CCN(CCCNc2nnc(-c3cccc(F)c3)c3c2cc2ccccn32)CC1 Show InChI InChI=1S/C26H29FN6O/c1-2-23(34)32-15-13-31(14-16-32)11-6-10-28-26-22-18-21-9-3-4-12-33(21)25(22)24(29-30-26)19-7-5-8-20(27)17-19/h3-5,7-9,12,17-18H,2,6,10-11,13-16H2,1H3,(H,28,30) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 4.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 1
(Homo sapiens (Human)) | BDBM86712
(CAS_868359-05-1 | N-[4-(2-BROMO-4,5-DIFLUOROPHENOX...)Show SMILES N[C@@H](CC(=O)Nc1ccc(Oc2cc(F)c(F)cc2Br)cc1)C(O)=O |r| Show InChI InChI=1S/C16H13BrF2N2O4/c17-10-5-11(18)12(19)6-14(10)25-9-3-1-8(2-4-9)21-15(22)7-13(20)16(23)24/h1-6,13H,7,20H2,(H,21,22)(H,23,24)/t13-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314579
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cc[n-][o+]3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C25H28N8O4/c1-17-15-20-23(30(17)2)22(18-5-3-6-19(16-18)33(35)36)28-29-24(20)26-8-4-10-31-11-13-32(14-12-31)25(34)21-7-9-27-37-21/h3,5-7,9,15-16H,4,8,10-14H2,1-2H3,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.08E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314569
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Cn1cccc1C(=O)N1CCN(CCCNc2nnc(-c3cccc(F)c3)c3c2cc2ccccn32)CC1 Show InChI InChI=1S/C29H30FN7O/c1-34-12-5-10-25(34)29(38)36-17-15-35(16-18-36)13-6-11-31-28-24-20-23-9-2-3-14-37(23)27(24)26(32-33-28)21-7-4-8-22(30)19-21/h2-5,7-10,12,14,19-20H,6,11,13,15-18H2,1H3,(H,31,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314573
((4-(3-(7-(3-chlorophenyl)-1,2-dimethyl-1H-pyrrolo[...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ncccn3)nnc(-c3cccc(Cl)c3)c2n1C Show InChI InChI=1S/C26H29ClN8O/c1-18-16-21-23(33(18)2)22(19-6-3-7-20(27)17-19)31-32-24(21)28-10-5-11-34-12-14-35(15-13-34)26(36)25-29-8-4-9-30-25/h3-4,6-9,16-17H,5,10-15H2,1-2H3,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 5.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
Excitatory amino acid transporter 3
(Homo sapiens (Human)) | BDBM86713
(WAY 213394 | WAY-213394)Show InChI InChI=1S/C17H18N2O3/c1-11-4-2-3-5-14(11)12-6-8-13(9-7-12)19-16(20)10-15(18)17(21)22/h2-9,15H,10,18H2,1H3,(H,19,20)(H,21,22)/t15-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| Article PubMed
| 6.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Wyeth Research
Curated by PDSP Ki Database
| |
Mol Pharmacol 68: 974-82 (2005)
Article DOI: 10.1124/mol.105.012005 BindingDB Entry DOI: 10.7270/Q2G44NVX |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314558
((4-(3-(4-phenylpyridazino[4,5-b]indolizin-1-ylamin...)Show SMILES O=C(N1CCN(CCCNc2nnc(-c3ccccc3)c3c2cc2ccccn32)CC1)c1cnccn1 Show InChI InChI=1S/C28H28N8O/c37-28(24-20-29-11-12-30-24)35-17-15-34(16-18-35)13-6-10-31-27-23-19-22-9-4-5-14-36(22)26(23)25(32-33-27)21-7-2-1-3-8-21/h1-5,7-9,11-12,14,19-20H,6,10,13,15-18H2,(H,31,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314578
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3ccccn3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C27H30N8O3/c1-19-17-22-25(32(19)2)24(20-7-5-8-21(18-20)35(37)38)30-31-26(22)29-11-6-12-33-13-15-34(16-14-33)27(36)23-9-3-4-10-28-23/h3-5,7-10,17-18H,6,11-16H2,1-2H3,(H,29,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.15E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314581
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cncs3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C25H28N8O3S/c1-17-13-20-23(30(17)2)22(18-5-3-6-19(14-18)33(35)36)28-29-24(20)27-7-4-8-31-9-11-32(12-10-31)25(34)21-15-26-16-37-21/h3,5-6,13-16H,4,7-12H2,1-2H3,(H,27,29) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
(Homo sapiens (Human)) | BDBM50314567
(CHEMBL1090031 | cyclopentyl(4-(3-(4-(3-fluoropheny...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)C2CCCC2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H33FN6O/c30-23-10-5-9-22(19-23)26-27-25(20-24-11-3-4-14-36(24)27)28(33-32-26)31-12-6-13-34-15-17-35(18-16-34)29(37)21-7-1-2-8-21/h3-5,9-11,14,19-21H,1-2,6-8,12-13,15-18H2,(H,31,33) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314561
(4-(3-chlorophenyl)-N-(3-(4-(pyrimidin-2-yl)piperaz...)Show SMILES Clc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27ClN8/c28-21-7-3-6-20(18-21)24-25-23(19-22-8-1-2-13-36(22)25)26(33-32-24)29-11-5-12-34-14-16-35(17-15-34)27-30-9-4-10-31-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,29,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.42E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314577
((4-(3-(1,2-dimethyl-7-(3-nitrophenyl)-1H-pyrrolo[3...)Show SMILES Cc1cc2c(NCCCN3CCN(CC3)C(=O)c3cccnc3)nnc(-c3cccc(c3)[N+]([O-])=O)c2n1C Show InChI InChI=1S/C27H30N8O3/c1-19-16-23-25(32(19)2)24(20-6-3-8-22(17-20)35(37)38)30-31-26(23)29-10-5-11-33-12-14-34(15-13-33)27(36)21-7-4-9-28-18-21/h3-4,6-9,16-18H,5,10-15H2,1-2H3,(H,29,31) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.53E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314560
(4-(3-bromophenyl)-N-(3-(4-(pyrimidin-2-yl)piperazi...)Show SMILES Brc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)c2ncccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C27H27BrN8/c28-21-7-3-6-20(18-21)24-25-23(19-22-8-1-2-13-36(22)25)26(33-32-24)29-11-5-12-34-14-16-35(17-15-34)27-30-9-4-10-31-27/h1-4,6-10,13,18-19H,5,11-12,14-17H2,(H,29,33) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.75E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314571
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H28FN7O/c30-22-8-5-7-21(19-22)26-27-24(20-23-9-2-4-14-37(23)27)28(34-33-26)32-12-6-13-35-15-17-36(18-16-35)29(38)25-10-1-3-11-31-25/h1-5,7-11,14,19-20H,6,12-13,15-18H2,(H,32,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314570
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cccnc2)c2cc3ccccn3c12 Show InChI InChI=1S/C29H28FN7O/c30-23-8-3-6-21(18-23)26-27-25(19-24-9-1-2-13-37(24)27)28(34-33-26)32-11-5-12-35-14-16-36(17-15-35)29(38)22-7-4-10-31-20-22/h1-4,6-10,13,18-20H,5,11-12,14-17H2,(H,32,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4D
(Homo sapiens (Human)) | BDBM50314568
((4-(3-(4-(3-fluorophenyl)pyridazino[4,5-b]indolizi...)Show SMILES Fc1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2ccccc2)c2cc3ccccn3c12 Show InChI InChI=1S/C30H29FN6O/c31-24-11-6-10-23(20-24)27-28-26(21-25-12-4-5-15-37(25)28)29(34-33-27)32-13-7-14-35-16-18-36(19-17-35)30(38)22-8-2-1-3-9-22/h1-6,8-12,15,20-21H,7,13-14,16-19H2,(H,32,34) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 2.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development
Curated by ChEMBL
| Assay Description Displacement of [methyl-3H]rolipram from PDE4D4 expressed in CHO cells after 1 hr by scintillation counting |
Bioorg Med Chem Lett 20: 2163-7 (2010)
Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54 |
More data for this Ligand-Target Pair | |