| Reaction Details |
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 | Report a problem with these data |
| Target | Prolyl endopeptidase FAP |
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| Ligand | BDBM50173968 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_328425 (CHEMBL863966) |
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| Ki | 14639±n/a nM |
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| Citation |  Haffner, CD; McDougald, DL; Reister, SM; Thompson, BD; Conlee, C; Fang, J; Bass, J; Lenhard, JM; Croom, D; Secosky-Chang, MB; Tomaszek, T; McConn, D; Wells-Knecht, K; Johnson, PR 2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV. Bioorg Med Chem Lett15:5257-61 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prolyl endopeptidase FAP |
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| Name: | Prolyl endopeptidase FAP |
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| Synonyms: | 170 kDa melanoma membrane-bound gelatinase | FAP | Fibroblast Activation Protein (FAP) | Fibroblast activation protein alpha | Integral membrane serine protease | SEPR_HUMAN | Seprase |
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| Type: | Enzyme |
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| Mol. Mass.: | 87712.48 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q12884 |
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| Residue: | 760 |
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| Sequence: | MKTWVKIVFGVATSAVLALLVMCIVLRPSRVHNSEENTMRALTLKDILNGTFSYKTFFPN
WISGQEYLHQSADNNIVLYNIETGQSYTILSNRTMKSVNASNYGLSPDRQFVYLESDYSK
LWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPP
FQITFNGRENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYG
DEQYPRTINIPYPKAGAKNPVVRIFIIDTTYPAYVGPQEVPVPAMIASSDYYFSWLTWVT
DERVCLQWLKRVQNVSVLSICDFREDWQTWDCPKTQEHIEESRTGWAGGFFVSTPVFSYD
AISYYKIFSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRVTQDSLFYSSNEFEEYPG
RRNIYRISIGSYPPSKKCVTCHLRKERCQYYTASFSDYAKYYALVCYGPGIPISTLHDGR
TDQEIKILEENKELENALKNIQLPKEEIKKLEVDEITLWYKMILPPQFDRSKKYPLLIQV
YGGPCSQSVRSVFAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQ
ITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASVY
TERFMGLPTKDDNLEHYKNSTVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA
QVDFQAMWYSDQNHGLSGLSTNHLYTHMTHFLKQCFSLSD
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| BDBM50173968 |
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| n/a |
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| Name | BDBM50173968 |
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| Synonyms: | (R)-3-amino-4-((2S,4S)-2-cyano-4-fluoropyrrolidin-1-yl)-2-methyl-4-oxobutane-2-sulfonic acid | CHEMBL199891 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H16FN3O4S |
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| Mol. Mass. | 293.315 |
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| SMILES | CC(C)([C@H](N)C(=O)N1C[C@@H](F)C[C@H]1C#N)S(O)(=O)=O |
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| Structure | 
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