| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Ligand | BDBM50597430 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2223430 (CHEMBL5136764) |
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| IC50 | >30000±n/a nM |
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| Citation |  Hill, MD; Blanco, MJ; Salituro, FG; Bai, Z; Beckley, JT; Ackley, MA; Dai, J; Doherty, JJ; Harrison, BL; Hoffmann, EC; Kazdoba, TM; Lanzetta, D; Lewis, M; Quirk, MC; Robichaud, AJ SAGE-718: A First-in-Class J Med Chem65:9063-9075 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Name: | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
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| Synonyms: | BCNG-2 | BCNG2 | Brain cyclic nucleotide-gated channel 2 | HCN2 | HCN2_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 96973.03 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_767273 |
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| Residue: | 889 |
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| Sequence: | MDARGGGGRPGESPGATPAPGPPPPPPPAPPQQQPPPPPPPAPPPGPGPAPPQHPPRAEA
LPPEAADEGGPRGRLRSRDSSCGRPGTPGAASTAKGSPNGECGRGEPQCSPAGPEGPARG
PKVSFSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL
RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET
TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP
VDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDL
ASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFALFK
AMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKY
KQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKLVA
SMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMK
LSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRL
DRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQQAELGQRVGLFPPPPPP
PQVTSAIATLQQAAAMSFCPQVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP
PGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRP
ASSSTPRLGPTPAARAAAPSPDRRDSASPGAAGGLDPQDSARSRLSSNL
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| BDBM50597430 |
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| n/a |
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| Name | BDBM50597430 |
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| Synonyms: | DALZANEMDOR | Dalzanemdor |
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| Type | Small organic molecule |
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| Emp. Form. | C27H43F3O2 |
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| Mol. Mass. | 456.6243 |
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| SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@@](C)(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C)[C@H](C)CC[C@](C)(O)C(F)(F)F |r,t:9| |
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| Structure | 
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