| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 8 |
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| Ligand | BDBM50597450 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2223456 (CHEMBL5136790) |
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| IC50 | 850±n/a nM |
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| Citation |  Tian, Y; Liu, K; Liu, R; Qiu, Z; Xu, Y; Wei, W; Xu, X; Wang, J; Ding, H; Li, Z; Bian, J Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ER? Expression. J Med Chem65:8914-8932 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 8 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 8 |
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| Synonyms: | Deubiquitinating enzyme 8 | KIAA0055 | UBP8_HUMAN | UBPY | USP8 | Ubiquitin isopeptidase Y | Ubiquitin thioesterase 8 | Ubiquitin-specific-processing protease 8 | hUBPy |
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| Type: | PROTEIN |
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| Mol. Mass.: | 127547.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_105200 |
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| Residue: | 1118 |
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| Sequence: | MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
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| BDBM50597450 |
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| n/a |
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| Name | BDBM50597450 |
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| Synonyms: | CHEMBL5208383 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H11N5O |
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| Mol. Mass. | 337.3342 |
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| SMILES | N#Cc1nc2\C(=N\OCc3ccccc3)c3ccccc3-c2nc1C#N |
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| Structure | 
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