Reaction Details |
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Target | Ubiquitin carboxyl-terminal hydrolase 8 |
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Ligand | BDBM50597454 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2223460 (CHEMBL5136794) |
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IC50 | 24500±n/a nM |
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Citation | Tian, Y; Liu, K; Liu, R; Qiu, Z; Xu, Y; Wei, W; Xu, X; Wang, J; Ding, H; Li, Z; Bian, J Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ER? Expression. J Med Chem65:8914-8932 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Ubiquitin carboxyl-terminal hydrolase 8 |
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Name: | Ubiquitin carboxyl-terminal hydrolase 8 |
Synonyms: | Deubiquitinating enzyme 8 | KIAA0055 | UBP8_HUMAN | UBPY | USP8 | Ubiquitin isopeptidase Y | Ubiquitin thioesterase 8 | Ubiquitin-specific-processing protease 8 | hUBPy |
Type: | PROTEIN |
Mol. Mass.: | 127547.92 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_105200 |
Residue: | 1118 |
Sequence: | MPAVASVPKELYLSSSLKDLNKKTEVKPEKISTKSYVHSALKIFKTAEECRLDRDEERAY
VLYMKYVTVYNLIKKRPDFKQQQDYFHSILGPGNIKKAVEEAERLSESLKLRYEEAEVRK
KLEEKDRQEEAQRLQQKRQETGREDGGTLAKGSLENVLDSKDKTQKSNGEKNEKCETKEK
GAITAKELYTMMTDKNISLIIMDARRMQDYQDSCILHSLSVPEEAISPGVTASWIEAHLP
DDSKDTWKKRGNVEYVVLLDWFSSAKDLQIGTTLRSLKDALFKWESKTVLRNEPLVLEGG
YENWLLCYPQYTTNAKVTPPPRRQNEEVSISLDFTYPSLEESIPSKPAAQTPPASIEVDE
NIELISGQNERMGPLNISTPVEPVAASKSDVSPIIQPVPSIKNVPQIDRTKKPAVKLPEE
HRIKSESTNHEQQSPQSGKVIPDRSTKPVVFSPTLMLTDEEKARIHAETALLMEKNKQEK
ELRERQQEEQKEKLRKEEQEQKAKKKQEAEENEITEKQQKAKEEMEKKESEQAKKEDKET
SAKRGKEITGVKRQSKSEHETSDAKKSVEDRGKRCPTPEIQKKSTGDVPHTSVTGDSGSG
KPFKIKGQPESGILRTGTFREDTDDTERNKAQREPLTRARSEEMGRIVPGLPSGWAKFLD
PITGTFRYYHSPTNTVHMYPPEMAPSSAPPSTPPTHKAKPQIPAERDREPSKLKRSYSSP
DITQAIQEEEKRKPTVTPTVNRENKPTCYPKAEISRLSASQIRNLNPVFGGSGPALTGLR
NLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHKGEVAEEFGIIMKALWTG
QYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNRKRYKEENNDH
LDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFMYLSLPLASTS
KCTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPVLLVHLKRFSYDGRW
KQKLQTSVDFPLENLDLSQYVIGPKNNLKKYNLFSVSNHYGGLDGGHYTAYCKNAARQRW
FKFDDHEVSDISVSSVKSSAAYILFYTSLGPRVTDVAT
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BDBM50597454 |
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n/a |
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Name | BDBM50597454 |
Synonyms: | CHEMBL5175647 |
Type | Small organic molecule |
Emp. Form. | C23H26N2O5 |
Mol. Mass. | 410.4629 |
SMILES | CC(C)Oc1c(O)cc(O)c2c1oc(cc2=O)-c1ccc(cc1)N1CCCNCC1 |
Structure |
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