| Reaction Details |
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 | Report a problem with these data |
| Target | tRNA (cytosine(38)-C(5))-methyltransferase |
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| Ligand | BDBM50009672 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_2223595 (CHEMBL5136929) |
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| Kd | 13600±n/a nM |
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| Citation |  Schwickert, M; Fischer, TR; Zimmermann, RA; Hoba, SN; Meidner, JL; Weber, M; Weber, M; Stark, MM; Koch, J; Jung, N; Kersten, C; Windbergs, M; Lyko, F; Helm, M; Schirmeister, T Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment. J Med Chem65:9750-9788 (2022) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| tRNA (cytosine(38)-C(5))-methyltransferase |
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| Name: | tRNA (cytosine(38)-C(5))-methyltransferase |
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| Synonyms: | 2.1.1.204 | DNA (cytosine-5)-methyltransferase-like protein 2 | DNA MTase homolog HsaIIP | DNA methyltransferase homolog HsaIIP | DNMT2 | M.HsaIIP | PuMet | TRDMT1 | TRDMT_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 44593.53 |
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| Organism: | Homo sapiens |
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| Description: | ChEMBL_118874 |
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| Residue: | 391 |
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| Sequence: | MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGI
TLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLEN
VKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPG
QVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHR
KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSY
IEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGF
PEKITVKQRYRLLGNSLNVHVVAKLIKILYE
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| BDBM50009672 |
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| n/a |
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| Name | BDBM50009672 |
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| Synonyms: | AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH) |
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| Type | Small organic molecule |
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| Emp. Form. | C14H20N6O5S |
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| Mol. Mass. | 384.411 |
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| SMILES | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |
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| Structure | 
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