Found 21 hits with Last Name = 'lyko' and Initial = 'f' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
DNA (cytosine-5)-methyltransferase 3B
(Homo sapiens (Human)) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
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CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation counting |
Bioorg Med Chem 18: 822-9 (2010)
Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Orphan methyltransferase M.SssI
(Spiroplasma monobiae strain MQ-1) | BDBM50180789
(1,2-bis(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-y...)Show InChI InChI=1S/C16H16N6/c1-11-5-7-21-13(17-19-15(21)9-11)3-4-14-18-20-16-10-12(2)6-8-22(14)16/h5-10H,3-4H2,1-2H3 | UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant CpG methylase M.SssI |
J Med Chem 49: 678-83 (2006)
Article DOI: 10.1021/jm050844z BindingDB Entry DOI: 10.7270/Q20G3JR2 |
More data for this Ligand-Target Pair | |
Orphan methyltransferase M.SssI
(Spiroplasma monobiae strain MQ-1) | BDBM50180790
(2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)prop...)Show SMILES OC(=O)C(Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25) | UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibition of recombinant CpG methylase M.SssI |
J Med Chem 49: 678-83 (2006)
Article DOI: 10.1021/jm050844z BindingDB Entry DOI: 10.7270/Q20G3JR2 |
More data for this Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 4.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting |
Bioorg Med Chem 18: 822-9 (2010)
Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597526
(CHEMBL5187166)Show SMILES CC(C#C)N(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.29E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50378739
(SINEFUNGIN | jm2c00120, Sinefungin)Show SMILES N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 1.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 1.58E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
DNA (cytosine-5)-methyltransferase 3B
(Homo sapiens (Human)) | BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)Show InChI InChI=1S/C15H12O6/c16-12-3-1-8(6-10(12)14(18)19)5-9-2-4-13(17)11(7-9)15(20)21/h1-4,6-7,16-17H,5H2,(H,18,19)(H,20,21) | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNMT3B expressed in baculovirus-insect cell system by scintillation counting |
Bioorg Med Chem 18: 822-9 (2010)
Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597525
(CHEMBL5202371)Show SMILES CCC#CCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597524
(CHEMBL5173553)Show SMILES CC#CCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 3.97E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50180790
(2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)prop...)Show SMILES OC(=O)C(Cc1c[nH]c2ccccc12)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C19H14N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h1-8,10,16,20H,9H2,(H,24,25) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibitory activity against DNA methyl transferase in leukemic NALM6 cells |
J Med Chem 49: 678-83 (2006)
Article DOI: 10.1021/jm050844z BindingDB Entry DOI: 10.7270/Q20G3JR2 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597523
(CHEMBL1091913)Show SMILES N[C@@H](CCN(CC#C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.71E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM11979
(5-[(3-carboxy-4-hydroxyphenyl)methyl]-2-hydroxyben...)Show InChI InChI=1S/C15H12O6/c16-12-3-1-8(6-10(12)14(18)19)5-9-2-4-13(17)11(7-9)15(20)21/h1-4,6-7,16-17H,5H2,(H,18,19)(H,20,21) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 9.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting |
Bioorg Med Chem 18: 822-9 (2010)
Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 |
More data for this Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50180789
(1,2-bis(7-methyl-[1,2,4]triazolo[4,3-a]pyridin-3-y...)Show InChI InChI=1S/C16H16N6/c1-11-5-7-21-13(17-19-15(21)9-11)3-4-14-18-20-16-10-12(2)6-8-22(14)16/h5-10H,3-4H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Polish Academy of Sciences
Curated by ChEMBL
| Assay Description Inhibitory activity against DNA methyl transferase in leukemic NALM6 cells |
J Med Chem 49: 678-83 (2006)
Article DOI: 10.1021/jm050844z BindingDB Entry DOI: 10.7270/Q20G3JR2 |
More data for this Ligand-Target Pair | |
DNA (cytosine-5)-methyltransferase 1
(Homo sapiens (Human)) | BDBM50308983
(2-(4-bromo-2-(4-(carboxymethoxy)benzoyl)phenoxy)ac...)Show SMILES OC(=O)COc1ccc(cc1)C(=O)c1cc(Br)ccc1OCC(O)=O Show InChI InChI=1S/C17H13BrO7/c18-11-3-6-14(25-9-16(21)22)13(7-11)17(23)10-1-4-12(5-2-10)24-8-15(19)20/h1-7H,8-9H2,(H,19,20)(H,21,22) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.12E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Deutsches Krebsforschungszentrum
Curated by ChEMBL
| Assay Description Inhibition of human recombinant DNMT1 expressed in baculovirus-insect cell system by scintillation counting |
Bioorg Med Chem 18: 822-9 (2010)
Article DOI: 10.1016/j.bmc.2009.11.050 BindingDB Entry DOI: 10.7270/Q2CF9Q69 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597525
(CHEMBL5202371)Show SMILES CCC#CCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.05E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597524
(CHEMBL5173553)Show SMILES CC#CCN(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.04E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597523
(CHEMBL1091913)Show SMILES N[C@@H](CCN(CC#C)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 1.14E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50378739
(SINEFUNGIN | jm2c00120, Sinefungin)Show SMILES N[C@@H](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| Show InChI InChI=1S/C15H23N7O5/c16-6(1-2-7(17)15(25)26)3-8-10(23)11(24)14(27-8)22-5-21-9-12(18)19-4-20-13(9)22/h4-8,10-11,14,23-24H,1-3,16-17H2,(H,25,26)(H2,18,19,20)/t6-,7-,8+,10+,11+,14+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
MCE MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | 7.50E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50009672
(AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocyst...)Show SMILES N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O Show InChI InChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1 | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | 1.36E+4 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
tRNA (cytosine(38)-C(5))-methyltransferase
(Homo sapiens) | BDBM50597526
(CHEMBL5187166)Show SMILES CC(C#C)N(CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12 |r| | PDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | n/a | 8.10E+3 | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.2c00388 BindingDB Entry DOI: 10.7270/Q2DJ5KN9 |
More data for this Ligand-Target Pair | |