Reaction Details |
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Target | tRNA (cytosine(38)-C(5))-methyltransferase |
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Ligand | BDBM50009672 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2223596 (CHEMBL5136930) |
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IC50 | 15800±n/a nM |
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Citation | Schwickert, M; Fischer, TR; Zimmermann, RA; Hoba, SN; Meidner, JL; Weber, M; Weber, M; Stark, MM; Koch, J; Jung, N; Kersten, C; Windbergs, M; Lyko, F; Helm, M; Schirmeister, T Discovery of Inhibitors of DNA Methyltransferase 2, an Epitranscriptomic Modulator and Potential Target for Cancer Treatment. J Med Chem65:9750-9788 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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tRNA (cytosine(38)-C(5))-methyltransferase |
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Name: | tRNA (cytosine(38)-C(5))-methyltransferase |
Synonyms: | 2.1.1.204 | DNA (cytosine-5)-methyltransferase-like protein 2 | DNA MTase homolog HsaIIP | DNA methyltransferase homolog HsaIIP | DNMT2 | M.HsaIIP | PuMet | TRDMT1 | TRDMT_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 44593.53 |
Organism: | Homo sapiens |
Description: | ChEMBL_118874 |
Residue: | 391 |
Sequence: | MEPLRVLELYSGVGGMHHALRESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGI
TLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQKLPKYILLEN
VKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPG
QVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHR
KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSY
IEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGF
PEKITVKQRYRLLGNSLNVHVVAKLIKILYE
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BDBM50009672 |
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n/a |
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Name | BDBM50009672 |
Synonyms: | AdoHcy | CHEMBL418052 | S-(5'-adenosyl)-L-homocysteine | S-(5'-deoxyadenosin-5'-yl)-L-homocysteine | S-[1-(adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl]-L-homocysteine | S-adenosyl-L-homocysteine | SAH | US8895245, S-Adenosyl-L-homocysteine (SAH) | US9175331, 1 | US9333217, S-Adenosyl-L-homocysteine (SAH) |
Type | Small organic molecule |
Emp. Form. | C14H20N6O5S |
Mol. Mass. | 384.411 |
SMILES | N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O |
Structure |
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