Reaction Details |
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Target | Pyruvate kinase PKM |
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Ligand | BDBM50134315 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_2224272 (CHEMBL5137785) |
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IC50 | 22640±n/a nM |
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Citation | Arora, S; Joshi, G; Chaturvedi, A; Heuser, M; Patil, S; Kumar, R A Perspective on Medicinal Chemistry Approaches for Targeting Pyruvate Kinase M2. J Med Chem65:1171-1205 (2022) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Pyruvate kinase PKM |
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Name: | Pyruvate kinase PKM |
Synonyms: | KPYM_HUMAN | OIP3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase (PKM2) |
Type: | Protein |
Mol. Mass.: | 57944.31 |
Organism: | Homo sapiens (Human) |
Description: | P14618 |
Residue: | 531 |
Sequence: | MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVET
LKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIR
TGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGL
ISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMV
FASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIE
IPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIM
LSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEAS
FKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQE
AWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
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BDBM50134315 |
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n/a |
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Name | BDBM50134315 |
Synonyms: | 7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione | CHEMBL331627 | GLIOTOXIN |
Type | Small organic molecule |
Emp. Form. | C13H14N2O4S2 |
Mol. Mass. | 326.391 |
SMILES | CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20| |
Structure |
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