| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine kinase |
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| Ligand | BDBM50174602 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321616 (CHEMBL872316) |
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| IC50 | 0.3±n/a nM |
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| Citation |  Boyer, SH; Ugarkar, BG; Solbach, J; Kopcho, J; Matelich, MC; Ollis, K; Gomez-Galeno, JE; Mendonca, R; Tsuchiya, M; Nagahisa, A; Nakane, M; Wiesner, JB; Erion, MD Adenosine kinase inhibitors. 5. Synthesis, enzyme inhibition, and analgesic activity of diaryl-erythro-furanosyltubercidin analogues. J Med Chem48:6430-41 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine kinase |
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| Name: | Adenosine kinase |
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| Synonyms: | ADK | ADK_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40545.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467841 |
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| Residue: | 362 |
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| Sequence: | MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH
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| BDBM50174602 |
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| n/a |
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| Name | BDBM50174602 |
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| Synonyms: | (4R,5R,6S)-5-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-4-oxa-spiro[2.4]heptane-6,7-diol | CHEMBL194294 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H21FN4O3 |
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| Mol. Mass. | 432.4469 |
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| SMILES | O[C@@H]1[C@H](O)C2(CC2)O[C@H]1n1cc(-c2ccccc2)c2c(Nc3ccc(F)cc3)ncnc12 |
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| Structure | 
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