Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50174677 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_326560 (CHEMBL863286) |
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IC50 | 24±n/a nM |
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Citation | Zhang, X; Urbanski, M; Patel, M; Zeck, RE; Cox, GG; Bian, H; Conway, BR; Pat Beavers, M; Rybczynski, PJ; Demarest, KT Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1. Bioorg Med Chem Lett15:5202-6 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50174677 |
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n/a |
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Name | BDBM50174677 |
Synonyms: | (2S,3R,4S,5S,6R)-2-(3-(2-(2,3-dihydrobenzofuran-5-yl)ethyl)-1H-indol-4-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol | CHEMBL200438 |
Type | Small organic molecule |
Emp. Form. | C24H27NO7 |
Mol. Mass. | 441.4737 |
SMILES | OC[C@H]1O[C@@H](Oc2cccc3[nH]cc(CCc4ccc5OCCc5c4)c23)[C@H](O)[C@@H](O)[C@@H]1O |
Structure |
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