Reaction Details |
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Target | Inosine-5'-monophosphate dehydrogenase 2 |
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Ligand | BDBM50174780 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_326856 (CHEMBL860455) |
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IC50 | 300±n/a nM |
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Citation | Birch, HL; Buckley, GM; Davies, N; Dyke, HJ; Frost, EJ; Gilbert, PJ; Hannah, DR; Haughan, AF; Madigan, MJ; Morgan, T; Pitt, WR; Ratcliffe, AJ; Ray, NC; Richard, MD; Sharpe, A; Taylor, AJ; Whitworth, JM; Williams, SC Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors. Bioorg Med Chem Lett15:5335-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Inosine-5'-monophosphate dehydrogenase 2 |
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Name: | Inosine-5'-monophosphate dehydrogenase 2 |
Synonyms: | IMDH2_HUMAN | IMP dehydrogenase 2 | IMPD 2 | IMPD2 | IMPDH-II | IMPDH2 | Inosine 5'-monophosphate dehydrogenase II (IMPDH II) | Inosine Monophosphate Dehydrogenase Type 2 (IMPDH2) | Inosine-5 -monophosphate dehydrogenase 2 | Inosine-5'-monophosphate dehydrogenase (IMPDH) |
Type: | Enzyme |
Mol. Mass.: | 55806.87 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant IMPDH2 expressed in E. coli. |
Residue: | 514 |
Sequence: | MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKIT
LKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVV
LSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDCFLEEIMT
KREDLVVAPAGITLKEANEILQRSKKGKLPIVNEDDELVAIIARTDLKKNRDYPLASKDA
KKQLLCGAAIGTHEDDKYRLDLLAQAGVDVVVLDSSQGNSIFQINMIKYIKDKYPNLQVI
GGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVP
VIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAM
DKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVR
AMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF
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BDBM50174780 |
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n/a |
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Name | BDBM50174780 |
Synonyms: | 7-methoxy-2,2-dimethyl-6-(oxazol-5-yl)-3-(2-(pyridin-4-yl)ethyl)-2,3-dihydroquinazolin-4(1H)-one | CHEMBL198791 |
Type | Small organic molecule |
Emp. Form. | C21H22N4O3 |
Mol. Mass. | 378.4244 |
SMILES | COc1cc2NC(C)(C)N(CCc3ccncc3)C(=O)c2cc1-c1cnco1 |
Structure |
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